angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...

purpose:  to determine whether angiotensin ii levels in aqueous humor is related to diabetes mellitus and to evaluate the effect of captopril. methods: in a case-control study, aqueous humor samples were obtained during cataract surgery from 58 eyes of 58 patients, of which 37 were diabetic. from these latter subjects, 16 had taken captopril (captopril group) and 21 had not taken any angiotensi...

the renin-angiotensin-aldosterone system (raas) plays pivotal roles in the pathogenesis of chronic kidney disease (ckd) progression and its increased complications such as hypertension (ht) and cardiovascular diseases (cvd). previous studies suggested that aliskiren a direct renin inhibitor, blocks raas and may be effective for the management of ckd and its complications. this review focuses on...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...

Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice. Materials and Methods: Male C57Bl mice (aged 4 and 14 months) were killed by CO2. The descending thoracic aorta was cleaned and dissected into rings. Aortic rings were mounted in Krebs’ solution at 37 °C an...

Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...

Background: Angiotensin converting enzyme (ACE) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin II that is a vasoconstrictor and mitogen factor. To date, the role of angiotensin II on regulating blood flow in inflamed joints has not been studied. Methods: Acute and chronic joint inflammation was induced in rabbits by intra-articular...