The Anti-angiogenic Activity of Phoenix dactylifera seeds methanol extract in vivo study Abstract: The aim of the study was to identify the antiangiogenic activity of Phoenix dactylifera seeds methanolic extract in vivo and the probable anti-angiogenic mechanism of action. The date seeds were extracted with methanol using cold method, the crude extract was tested on chick chorioallantoic ...

preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. early diagnosis and management of disease could reduce its potential side effects. the vascular endothelial growth factor (vegf) family including vegf-a is the most potent endothelial growth factor which induces angiogenesis and endothelial cel...

Angiogenesis is one of the main processes that coordinate biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute pregnancy’s physiology pathophysiology, fetal–maternal interaction. The present review outlines implications EV-mediated cr...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

background: mesenchymal stem cells (mscs) are recently introduced as novel immunological gene carriers for treatment of cancer. it is believed that balance between the expression of angiogenic and anti-angiogenic factors, such as sdf-1 and ip-10, may regulate neovascularization within the tumor. methods: in this study, we compared the expression of important tumor promoting mediators in ip-10-t...

Aging is the strongest risk factor for cardiovascular disease, with progressive decline in function of vascular endothelial cells (ECs) age. Systematic analyses effects aging on different cardiac EC types remain limited. Here, we constructed a scRNA atlas transcriptomes young and old mouse hearts. We identified 10 subclusters. The multidimensionally differential genes (DEGs) analysis across clu...