In the past decades, lung cancer is considered one of lethal cancers all across world due to its evidenced greatest mortality and morbidity. Currently, main clinical treatment methods for involve surgery, chemotherapy, radiotherapy, anti-angiogenesis inhibitors tyrosine kinase inhibitors. field anticancer drugs, a variety new drugs have been emerging in recent years. They include chemotherapy w...

Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently, however, vascular endothelial cells themselves have been found to produce angiogenesis inhibitors including vasohibin-1. These intrinsic inhibit...

Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. ...

background and objectives: angiogenesis is essential for tumor survival. inhibiting angiogenesis could be a mechanism for hindering tumor development. numerous studies have now been focused on agiogenesis inhibitors and many of such studies have targeted plant materials. in the present study, crocus pallasii subsp. haussknechtii has been evaluated for anti-angiogenesis properties. methods: anti...

Abstract The development of new therapies for cancer has led to dramatic improvements in survivorship. Angiogenesis inhibitors represent one such advancement, revolutionising treatment a wide range malignancies. However, these drugs are associated with cardiovascular toxicities which can impact optimal the short-term and may lead increased morbidity mortality longer term. Vascular endothelial g...

Background and objectives: Angiogenesis is essential for tumor survival. Inhibiting angiogenesis could be a mechanism for hindering tumor development. Numerous studies have now been focused on agiogenesis inhibitors and many of such studies have targeted plant materials. In the present study, Crocus pallasii subsp. haussknechtii has been evaluated for anti-angiogenesi...

G protein-coupled receptors (GPCRs) are important classes of cell surface involved in multiple physiological functions. Aberrant expression, upregulation, and mutation GPCR signaling pathways frequent many types cancers, promoting hyperproliferation, angiogenesis, metastasis. Recent studies showed that alterations GPCRs different lymphoma types. Herein, we review the synthetic strategies to obt...