The purpose of this study was to investigate the protective effects of Terpinen-4-ol (TER) on dextran sulfate sodium (DSS)-induced experimental colitis and clarify the possible mechanisms. In vivo, an acute colitis model was used to confirm the anti-inflammatory activity and the possible mechanisms of TER in C57BL/6 and NLRP3-/- mice. In vitro, we performed further study, using RAW264.7 cells a...

Very long-chain fatty acids (VLCFAs, chain length >C20) exist in tissues throughout the body and are synthesized by repetition of the fatty acid (FA) elongation cycle composed of four successive enzymatic reactions. In mammals, the TER gene is the only gene encoding trans-2-enoyl-CoA reductase, which catalyzes the fourth reaction in the FA elongation cycle. The TER P182L mutation is the pathoge...

A bottleneck for medical domain Temporal Expression Recognition (TER) is the availability of data. An open-domain TER system may not be able to capture domain-specific expressions, while domain-specific TER may be cumbersome to implement. We present a novel neural network based medical TER system that uses corpora from news and medical domains. Thus, it serves as a middle ground between an open...

A bottleneck for medical domain Temporal Expression Recognition (TER) is the availability of data. An open-domain TER system may not be able to capture domain-specific expressions, while domain-specific TER may be cumbersome to implement. We present a novel neural network based medical TER system that uses corpora from news and medical domains. Thus, it serves as a middle ground between an open...

this paper, following a formalist approach, attempts to explain art as a zeitgeist, or 'spirit of the age'. it is aimed to investigate the enhancement of the painting by armenian artists of isfahan on the bases of historical literature and documents left since 17th, 18th and 19th century, as well as the available secondary sources tries to examine the iranian–armenian community's...

OBJECTIVE Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the cornea of live rabbit eyes. TER was measured and TER change after instillation of...

BACKGROUND Proteins are exported from the ER at transitional ER (tER) sites, which produce COPII vesicles. However, little is known about how COPII components are concentrated at tER sites. The budding yeast Pichia pastoris contains discrete tER sites and is, therefore, an ideal system for studying tER organization. RESULTS We show that the integrity of tER sites in P. pastoris requires the p...