Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected mal...

Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention researchers for exhibiting number notable biological properties. Herein, we describe routes to synthesize bioactive synthetic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as starting material. The methods proved remarkably efficient achieve target compounds comprise synt...

Several techniques have been proposed for adding persistence to the Java language environment. This paper describes a system we call icee that works by checkpointing the Java Virtual Machine. We compare the scheme to other persistent Java techniques. Checkpointing offers two unique advantages: first, the implementation is independent of the JVM implementation, and therefore survives JVM updates...