The DNA region encoding biphenyl dioxygenase, the first enzyme in the biphenyl-polychlorinated biphenyl degradation pathway of Pseudomonas species strain LB400, was sequenced. Six open reading frames were identified, four of which are homologous to the components of toluene dioxygenase from Pseudomonas putida F1 and have been named bphA, bphE, bphF, and bphG. From this comparison, biphenyl diox...

The science of medical genetics is progressing rapidly. The practical importance of this pro­gress should be considered by medical doctors. Both genetic and environmental factors are involved in the abnormail phenotypes considered diseases. The relative significance of the two factors varies from disease to disease. All di­seases can be viewed as falling on a spectrum in this regard. Hereditary...

hemophagocytic lymphohistiocytosis (hlh) is an aggressive and potentially life-threatening disease and has to be considered in the differential diagnosis of many conditions. hlh comprises two different conditions that are difficult to differentiate; familial hemophagocytic lymphohistiocytosis (fhlh) or familial erythrophagocytic lymphohistiocytosis (fel), and secondary hemophagocytic syndromes ...

background pe5 is a member of the pe protein family whose precise function is yet to be understood. there are about 100 members of the pe family proteins in mycobacterium tuberculosis. these glycine- and alanine-rich proteins consist of proline-glutamate motifs at their n-termini and may be implicated in pathogenesis of the bacilli. objectives we aimed to clone and over-express the rv0285 codin...

anxiety comprises many clinical descriptions and phenotypes. a genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-ht) transporter (5-htt) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. complete genome-wide linkage s...

background :the cag pathogenicity island includes a number of genes, including cytotoxin-associated protein a (caga) and vacuolatingcytotoxin (vaca) genotypes, which are associated with bacterial virulence. although the role of caga and vaca in the virulence of helicobacter pylori (h. pylori) is well-established in epidemiological studies, the relationship between the caga and vaca genotypes in...

conclusions data reported here indicated that there is no specific genetic combination beyond the quantity of biofilm biomass in s. epidermidis. biofilm biomass seemed to be controlled by rnaiii expression level. further interest should be directed to biofilm dispersal since it seems that the key difference in biofilm biomass ability of s. epidermidis strains relates to factors regulating this ...

conclusions our results indicate that acetylation genes have an important role in aminoglycoside resistance of the enterococcus isolates from clinical samples. moreover, salmonella strains indicate very low level of aminoglycoside resistance, and aminoglycoside resistance genes were not found in salmonella isolates. these results indicate that other resistance mechanisms, including efflux pumps...

background systemic candidiasis is a major public health concern. in particular, in immunocompromised people, such as patients with neutropenia, patients with acquired immune deficiency syndrome (aids) and cancer who are undergoing antiballistic chemotherapy or bone marrow transplants, and people with diabetes. since the clinical signs and symptoms are nonspecific, early diagnosis is often diff...