peptaibols in microbial culture extracts3~5). Here we report the isolation and structure elucidation of peptaibolin (1, Fig. 1) as an unusual representative of the peptaibol family of lipophilic antibiotics. 1 was disclosed in two fungal strains, Sepedonium sp. HKI-0117 and Sepedonium ampullosporum HKI-0053 coproducing the neuroleptic peptaibol-type antibiotic ampullosporin5). In contrast to th...

“We also thank the Brazilian Agencies CNPq, CAPES, FUNCAP and FINEP, the FUNCAP/CNPq Pronex grant, and the National Institute of Science and Technology for Complex Systems in Brazil for financial support. Hernan Makse thanks NIH and Army Research Laboratory Cooperative Agreement Number W911NF-09-2-0053 (the ARL Network Science CTA) for financial support. We thank Prof. César Barreira for valuab...

[email protected] 1 Graduate school of Science and Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi 316-8511, Japan 2 Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan 3 Satellite Venture Business Laboratories (part of NEDO), Graduate school of Science and Engineering,...

“We thank C. Briscoe, J.F. Eichner, L.K. Gallos, and H.D. Rozenfeld for useful discussions. This work was supported by National Science Foundation Grants NSF-SES-0624116 and NSF-EF-0827508 and Army Research Laboratory Cooperative Agreement Number W911NF-09-2-0053 (the ARL Network Science CTA). F.L. acknowledges financial support from The Swedish Bank Tercentenary Foundation. S.H. thanks the Eur...

Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan 1Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan 2Division of Research and Development, MedTech Heart Inc., 3-24-8 Asakusabashi, Taito-ku, Tokyo 111-0053, Japan 3School o...

Background & AimsTreatments are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can reduce symptoms nausea and vomiting. We investigated the safety efficacy tradipitant, an antagonist NK1R, in patients with idiopathic or diabetic gastroparesis.MethodsWe performed a double-blind trial 152 adults gastroparesis at 47 sites United States from November 2016 t...