introduction: alzheimer’s disease (ad) is one of the most common neurodegenerative disorders, which has much benefited from animal models to find the basics of its pathophysiology. in our previous work (haghani, shabani, javan, motamedi, & janahmadi, 2012), a non-transgenic rat model of ad was used in electrophysiological studies. however, we did not investigate the histological aspects in the ...

Objective: Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of amyloid beta in the hippocampus. In recent decades, herbal medicine has been widely used to treat many neurodegenerative disorders,as in comparison to conventional drugs, herbal remedies exert minimal side effects. Here, the effects of thymoquinone, as the main active component of Nigella sativa, on ...

The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer's disease (AD) has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production and clearance of Aβ. There is emerging evid...

Background and objectives: Alzheimer's disease (AD) as a neurodegenerative disorder is the most common form of dementia in the elderly. According to the amyloid hypothesis, accumulation of amyloid beta (Aβ) plaques, which are mostly constituted of Aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. Thus, modulation of Aβ toxicity is the hopef...

Extracellular and intraneuronal accumulation of amyloid-beta aggregates has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). However, the precise mechanism of amyloid-beta neurotoxicity is not completely understood. Previous studies suggest that binding of amyloid-beta to a number of macromolecules has deleterious effects on cellular functions. Mitochondria were...

Alzheimer’s Disease (AD) is a progressive neurological disorder associated with cognitive and memory deficits. Accumulation of amyloid beta (Aβ) plaques is one of the major causes of AD. Therefore, inhibition of the plaque formation has been aimed to play a preventive role in the disease. Lavender, through some neuroprotective roles such as antioxidant effects, is known to be an effective c...

Abstract Background The earliest cognitive changes in Alzheimer’s disease (AD), even before amyloid‐beta (Aβ) is abnormal, remain largely unclear. We recently observed a cohort of cognitively normal older monozygotic twins that 15% twin‐pairs were discordant for Aβ status (Fig. 1). In this cohort, we investigated early by comparing decline over 4 years among (one twin and co‐twin abnormal Aβ), ...

The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition of amyloid beta (Aβ) protein. Findings that Aβ production occurs largely in end...

Oxidative stress is one of the pathological mechanisms responsible for the beta- amyloid cascade associated with Alzheimer's disease (AD). Previous studies have demonstrated the role of carnosic acid (CA), an effective antioxidant, in combating oxidative stress. A progressive cognitive decline is one of the hallmarks of AD. Thus, we attempted to determine whether the administration of CA protec...

Background Cerebral beta-amyloid (Aβ) is a hallmark of AD. Few studies have revealed which the regional Aβ markers are associated with abnormal levels status. The aim current study was to identify multivariate predicting positivity (Aβ+). Method Seven hundred and sixty-five participants from ADNI-2 cohort at baseline visit were included in study. We used uptake as predictors predictive model. F...