Previous studies have shown that intra-accumbens infusion of isoproterenol (ISO), a beta-adrenoceptor-agonist, and phenylephrine (PE), an alpha-adrenoceptor-agonist, increase the release of accumbal dopamine (DA). In the present study we analyzed whether the ISO-induced release of DA is sensitive to pretreatment with the DA synthesis inhibitor alpha-methyl-para-tyrosine (AMPT). Earlier studies ...

BACKGROUND Bulimia nervosa (BN) has been associated with dysregulation of the central catecholaminergic system. An instructive way to investigate the relationship between catecholaminergic function and psychiatric disorder has involved behavioral responses to experimental catecholamine depletion (CD). The purpose of this study was to examine a possible catecholaminergic dysfunction in the patho...

BACKGROUND The brain reward circuitry innervated by dopamine is critically disturbed in schizophrenia. This study aims to investigate the role of dopamine-related brain activity during prediction of monetary reward and loss in first episode schizophrenia patients. METHODS We measured blood-oxygen-level dependent (BOLD) activity in 10 patients with schizophrenia (SCH) and 12 healthy controls d...

We argue that the ratio S 3 = ΛH/( 3He × Λp ) is a good representation of the local correlation between baryon number and strangeness, and therefore is a valuable tool to probe the nature of the dense matter created in high energy heavyion collision: quark gluon plasma or hadron gas. A multiphase transport model (AMPT) plus a dynamical coalescence model is used to elucidate our arguments. We fi...

BACKGROUND A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hormone leptin. METHODS Using a randomized, double-blind, placebo-controlled, crossover design, a r...

Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to...

TOPMODEL rainfall-runoff hydrologic concepts are based on soil saturation processes, where soil controls on hydrograph recession have been represented by linear, exponential, and power function decay with soil depth. Although these decay formulations have been incorporated into baseflow decay and topographic index computations, only the linear and exponential forms have been incorporated into i...

The azimuthal anisotropy of hadron transverse momentum distributions in heavy ion collisions at RHIC is sensitive to the properties of produced matter. In the framework of transport approach, it was shown in Ref.[ 1] using the ZPC model [ 2] that the value of the second harmonic, i.e., the elliptic flow, depends sensitively on the magnitude of parton scattering cross sections. With a more reali...

The multiplicity and elliptic flow of charged particles produced in Pb-Pb collisions at center of mass energy √ sNN = 2.76 TeV from the Large Hadron Collider are studied in a multiphase transport (AMPT) model. With the standard parameters in the HIJING model, which is used as initial conditions for subsequent partonic and hadronic scatterings in the AMPT model, the resulting multiplicity of fin...