Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...

• IF 1 regulates MCU-dependent mitochondrial Ca 2+ uptake. loss induces MCU upregulation through activation of the AMPK/CREB pathway. OMA1 depletion restores physiological levels and entry.

Chronic muscle loading (overload) induces skeletal muscles to undergo hypertrophy and increase glucose uptake. Although AMP-activated protein kinase (AMPK) reportedly serves as a negative regulator of positive uptake, its role in overload-induced uptake is unclear. This study aimed determine whether AMPK regulates muscles. To this end, overload was induced through unilateral synergist ablations...

The 5´-AMP-activated protein kinase (AMPK) is a key regulator of cellular metabolism and energy homeostasis in mammalian tissues. Metabolic adaptation is a critical step in ensuring cell survival during metabolic stress. Because of its critical role in the regulation of glucose homeostasis and carbohydrate, lipid, and protein metabolism, AMPK is involved in many human diseases, including cancer...

To investigate the protective effects of galangin on liver toxicity induced by carbon tetrachloride (CCl 4 ) in mice. Mouse hepatotoxicity model was established intraperitoneal injection (i.p.) 10 ml/kg body weight CCl that diluted with corn oil to a proportion 1:500 Kunming The mice were randomly divided into five groups named control group, and 1, 5, mg/kg group. levels alanine aminotransfera...

OBJECTIVES AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). MATERIALS AND METHODS The SCI model was established in rats in vivo and the primary spinal cord neurons were subjecte...

signaling amp-activated protein kinase (ampk), an energy sensing enzyme, has been implicated in controlling inflammation. in this study we investigated whether activation of ampk by metformin could protect the lung from lipopolysaccharide (lps)-induced acute injury by inhibitingng tlr4 pathway. male wistar rats were randomly divided into 3 groups (n=6): control group received normal saline (0.5...

Urocortin 2 (Ucn2), a peptide of the corticotropin-releasing factor (CRF) family, binds with high affinity to type 2 CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/reperfusion. The mechanisms by which the Ucn2-CRFR2 axis mitigates against ischemia/reperfusion injury remain incompletely delineated. Activation of AMP-activated protein kinase (AMPK) also limits car...