sepsis as the host responsive syndrome is one of the main concerning issues and costly disease on intensive care unit (icu) in the 21st century. epidemiological studies have showed that mortality rates of sepsis in icu and hospitals among 37 countries were 39.2% and 49.6% respectively [1].  complicated nature of sepsis is still not well understood and this makes it hard to treat and manage. acc...

To investigate the protective effects of galangin on liver toxicity induced by carbon tetrachloride (CCl 4 ) in mice. Mouse hepatotoxicity model was established intraperitoneal injection (i.p.) 10 ml/kg body weight CCl that diluted with corn oil to a proportion 1:500 Kunming The mice were randomly divided into five groups named control group, and 1, 5, mg/kg group. levels alanine aminotransfera...

The aim of the paper is to explore whether AMPK/UlK1 signaling pathway involved in regulating autophagy and alleviating cerebral ischemia/reperfusion (I/R) injury. On this basis, study regulatory effect Buyang Huanwu Decoction (BHD) on pathway, aiming clarify molecular mechanism BHD I/R injury protective containing serum (BHDS) OGD/R neurons. research group adopted following methods: Neurons cu...

ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. metformin can either protect or damage cells by activating amp-activated protein kinase (ampk) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...

Policosanol is known as a hypocholesterolemic compound and derived from plants such sugar cane corn. can lower blood pressure or inhibit adipogenesis, but its effect on osteogenic differentiation the molecular mechanism unclear. This study aims to investigate of policosanol in MC3T3-E1 cells zebrafish models. Administration into induced expression genes distal-less homeobox 5 (Dlx5) runt-relate...

background: the purpose of this study is to evaluate effects of teucrium polium (tp) leaf extracts on adenosine monophosphate activated protein kinase (ampk) level in isolated pancreases. materials and methods: in this experimental study, two groups of rats were used as a control group, and diabetic group. in the end of experimental period the animals were sacrificed then pancreas were removed,...

Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...