It has been shown (Odegaard, 1962) by sensitivity testing in vitro that the effect of ampicillin on most gonococcal strains is somewhat weaker than that of penicillin G, but the effect on strains less sensitive is better with ampicillin than with penicillin G. Reyn and Bentzon (1968), in support of this, found that the 50 per cent. inhibitory concentrations for the naturally-occurring more sens...

An impurity of Ampicillin sodium formed during a gradient reverse phase high performance liquid chromatography (HPLC) analysis of stress stability samples of the drug substance Ampicillin sodium, and the level of this impurity was found at up to 0.9%. This impurity was identified by LC-MS and characterized by (1H NMR, LC/MS/MS, elemental analysis). Based on the spectral data, the impurity was n...

We studied nine solid and two liquid media for their suitability to select Aeromonas and Plesiomonas spp. from human stools, using artificially contaminated samples as well as 254 samples from outpatients with and without diarrhea. Media with optimal sensitivity and specificity for Aeromonas spp. were alkaline peptone-water, Trypticase soy broth with ampicillin, inositol-brilliant green-bile sa...

OBJECTIVES To document the trend of ampicillin-resistant infections in newborns weighing at least 1500 g and to determine factors associated with ampicillin-resistant neonatal early-onset infection in the era of routine group B streptococcal prophylaxis. DESIGN Case-control study. SETTING Referral hospital with level I through level III nurseries.Patients Newborns aged 0 to 7 days with cult...

Certain stimuli at the gut barrier may be necessary in early life to establish a proper balance of immune tolerance. We evaluated a compromised barrier in juvenile mice in relation to microbiota and local and systemic immunity. BALB/c mice were treated with a low dose of dextran sulfate sodium (DSS) with or without ampicillin and lipopolysaccharide (LPS) to clarify the importance of microbial a...

Porphyromona gingivalis and Parvimonas micra are anaerobic microorganisms that usually found in the normal oral microbiome. Bacteremia is rarely caused by P. there have been no reports of splenic abscess micra. Treatments for include vancomycin, ceftriaxone, metronidazole, while treatments tetracyclines, macrolides, beta-lactam penicillins, clindamycin. We report a case 76-year-old caucasian ma...

Purpose: To develop ampicillin trihydrate-loaded chitosan nanoparticles by modified ionic gelation method and evaluate their antimicrobial activity. Methods: Ampicillin trihydrate-loaded chitosan nanoparticles were prepared by ionic gelation method with the aid of sonication. Parameters such as the zeta potential, polydispersity, particle size, entrapment efficiency and in vitro drug release of...