background :   ampc β-lactamases are important cephalosporinases chromosomally encoded in many of enterobacteriaceae and a few other organisms where they mediate resistance to cephalothin, cefazolin, cefoxitin and penicillins. the six different families of plasmid-mediated ampc β-lactamases have been described, but no phenotypic test can discriminate among them. ampc multiplex pcr has been succ...

BACKGROUND Extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases enzyme are major sources of resistance to β-lactam antibiotics especially in Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae. Increasing frequency of the co-existence of ESBLs with AmpC-β-lactamases in bacteria is a serious threat for treating bacterial infections. OBJECTIVES The aim of this study wa...

AmpC β-lactamase enzymes confer resistance to a wide variety of β-lactam antibiotics, except carbapenems. AmpC β-lactamase-producing bacteria are known to be causative pathogens of nosocomial infections, which are difficult to be treated. Hence, this study was aimed out to determine the prevalence of AmpC β-lactamase enzyme production among Gram-negative bacteria. A total of 500 multidrug-resis...

The incidence of resistance by Enterobacteriaceae to β-lactam/β-lactamase inhibitors combination is increasing in Egypt. Three phenotypic techniques, comprising AmpC disk diffusion and inhibition dependent methods using phenylboronic acid (PBA) and cloxacillin, were compared to PCR based method for detection of plasmid mediated AmpC β-lactamase in common urinary tract isolates. A total of 143 i...

There are few studies on the presence of extended-spectrum β-lactamases and AmpC β-lactamases (ESBL/AmpC) in bacteria that contaminate vegetables. The role of the production environment in ESBL/AmpC gene transmission is poorly understood. The occurrence of ESBL/AmpC in Escherichia coli (n = 46) from lettuce and irrigation water and the role of irrigation water in the transmission of resistant E...

BACKGROUND Proteus species cause a variety of community- and hospital-acquired illnesses. Synthesis of β-lactamases is the predominant mechanism for resistance to β-lactam antibiotics. Among the β-lactamases, extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases are the most common. AIM The objective of this study was to determine the occurrence of ESBL and AmpC β-lactamases in Proteus...

background: in order to select a better antibiotic choice for treatment of pseudomonas aeruginosa infections, this study was conducted to determine the frequency of resistance to some antipseudomonal β-lactams in p. aeruginosa isolates from patients in tehran, iran. in addition, the relation between presence of genes known to be responsible for resistance to β-lactams (ampc, mexc1,2,and mexc3,4...

The widespread use of β-lactam antibiotics has lead to the development of resistance to this group of antibiotics in bacterial pathogens due to various types of β lactamase production. Amongst the mechanisms of resistance to third generation cephalosporins, production of extended spectrum β-lactamases (ESBLs) and AmpC β lactamases is the most common1. Since both ESBL and AmpC β-lactamase are en...

conclusions biofilm formation (both strong and weak) strongly correlated with psla gene carriage. biofilm formation also correlated with mbl and ampc β-lactamase production. more importantly, multiple-β-lactamase phenotype was associated with formation of strong biofilms. results biofilm formation was observed in 43.5% of the isolates, of which 66.7% produced strong and 33.3% formed weak biofil...