introduction: breast cancer is the most common cancer in women worldwide and her-2 is one importantly prognostic factor in this cancer. tumor markers use as a criterion for predicting recurrence, but in breast cancer physical examination and mammography are important factors that are recommended for following up the recurrence. the aim of this study was to assess the correlation between breast ...

male breast cancer is a rare disease with an increasing trend. due to limited information especially about the genetic basis of the disease in iran and the lower age of its onset, the disease requires more attention. the aim of this study was to screen the male patients with breast cancer for brca mutations as well as tissue markers of estrogen receptor (er), progesterone receptor (pr), human e...

conclusions this study suggests that decrease in levels of tlr3 and tlr7 expression is a mechanism that may enable hcv to evade the host innate immune response. results in both groups, we had 13 males and 12 females with a mean age of 48.7 ± 16. tlr3 (6.23 ± 0.91 vs. 3.89 ± 0.85, p < 0.001) and tlr7 (1.48 ± 0.82 vs-1.33 ± 1.18, p < 0.001) expressions were significantly lower in patients with ch...

introduction: previous studies have indicated that stress levels of glucocorticoid hormones induce impairment of long term memory retrieval, but the underlying mechanisms (genomic or non-genomic) are not clear. to clarify this issue, we investigated the involvement of brain corticosteroid receptors and protein synthesis in the glucocorticoid-induced impairment of memory retrieval. methods: 140 ...

conclusions anesthesiologists need to be aware of dextromethorphan’s clinical pharmacology because recreational abuse of the drug has become increasingly common in adolescents and young adults. case presentation a 30-year-old man with a history of a nasal fracture was scheduled to undergo an elective septorhinoplasty. he reported daily consumption of large quantities (1440 to 1800 mg) of dextro...

anti-n-methyl-d-aspartate receptor (anti-nmdar) encephalitis is is most common form ofimmune-mediated encephalitis with prominent neurologic and psychiatric features at disease onset. we describe a 16 years old patient who presented with fever and status epilepticus. his mri sequences was normal. anti-nmdar antibodies were detected in the csf.  mri, ct and other studies didn,t show any tumor.

dopamine (da) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. the dopaminergic system is the primary therapeutic target in the treatment of parkinson’s disease (pd), drug addiction and schizophrenia. notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

introduction: it has been shown that administration of win55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (bla), dose-dependently increases the thermal latency to withdrawal in the tail-.ick test and decreases pain related behaviors in both phases of the formalin test. recent human and animal imaging data suggest that the nucleus accumbens (nac) is an important neural su...

Yang, Guang, Gang Chen, Timothy J. Ebner, and Costantino Iadecola. Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1760–R1770, 1999.—Crus II is an area of the cerebellar cortex that receives trigeminal afferents from the perioral region. We investigated the mechanisms of fu...