Rapoport and Kottwitz defined the affine Deligne-Lusztig varieties X w̃ (bσ) of a quasisplit connected reductive group G over F = Fq((t)) for a parahoric subgroup P . They asked which pairs (b, w̃) give non-empty varieties, and in these cases what dimensions do these varieties have. This paper answers these questions for P = I an Iwahori subgroup, in the cases b = 1, G = SL2, SL3, Sp4. This infor...

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2'-O-Methyl (2'OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2'OMe AMOs to inhibit Toll-like receptor (TLR) 7 and 8 sensing of immunostimulatory RNA, independent of their miRNA-targeting function. Through a scr...

BACKGROUNDS To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. METHODS Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Th...

fails to resolve, demonstrating that, as with the selection of other neural precursors, the resolution of amos expression involves lateral inhibition. In the antennal imagi-nal disc, amos mRNA is detected in three semicircular The peripheral nervous system (PNS) is made up of an bands that correspond to the sites where olfactory sen-array of different sensory structures that detect aspects sill...

In this paper we present AmOS, the Ambient Object System that underlies the Ambience programming language. AmOS implements a computation model that supports highly dynamic behaviour adaptation to changing contexts. Apart from being purely object-based, AmOS features first-class closures, multimethods and contexts. Dynamic method scoping through a subjective dispatch mechanism is at the heart of...

We explain, in the case of good reduction, the conjecture of Langlands and Rapoport describing the structure of the points on the reduction of a Shimura variety (Langlands and Rapoport 1987, 5.e, p169), and we derive from it the formula conjectured in (Kottwitz 1990, 3.1), which expresses a certain trace as a sum of products of (twisted) orbital integrals. Also we introduce the notion of an int...

In an article published in this journal, Rapoport and Amaldoss [Rapoport, A., Amaldoss, W., 2000. Mixed strategies and iterative elimination of strongly dominated strategies: an experimental investigation of states of knowledge. Journal of Economic Behavior and Organization 42, 483–521] analyze symmetric and asymmetric investment games similar to two-player all-pay auctions with bid caps. In th...

We prove the local Kudla–Rapoport conjecture, which is a precise identity between arithmetic intersection numbers of special cycles on unitary Rapoport–Zink spaces and derivatives representation densities hermitian forms. As first application, we global relates Shimura varieties central Fourier coefficients incoherent Eisenstein series. Combining previous results Liu Garcia–Sankaran, also cases...

Present databases, whether on centralized or parallel DBMSs, do not deal well with scalability. We present an architecture for Wintel multicomputers termed AMOS-SDDS, coupling a high-performance main-memory DBMS AMOS-II and a manager of Scalable Distributed Data Structures SDDS-2000. SDDS-2000 provides the scalable data partitioning in distributed RAM, supporting parallel scans with function sh...