An isocratic reversed-phase liquid chromatograpic assay method was developed for the quantitative determination of amlodipine besylate (AML) and indapamide (IND) in combined dosage form. A Brownlee C-18, 5 μm column with a mobile phase containing 0.02 M potassium dihydrogen phosphate-methanol (30+70, v/v) total pH-adjusted to 3 using o-phosphoric acid was used. The flow rate was 1.0 mL min(-1) ...

A new simple, rapid, specific, accurate, precise and novel reverse phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the simultaneous estimation of Ramipril and amlodipine besylate in the combined pharmaceutical dosage form. The chromatographic separation for ramipril and amlodipine besylate were achieved with mobile phase containing mixed phosphate buffer (0....

A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of amlodipine besylate, valsartan and hydrochlorothiazide in combination in bulk mixture and tablet. The estimation was based upon measurement of absorbance at absorbance maxima of 359 nm, 317 nm and 250 nm for amlodipine besylate, hydrochlorothiazide and valsartan in methano...

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method has been developed and validated for the determination of Nebivolol hydrochloride and S-amlodipine besylate in combined dosage form. The method obeys Beer’s Law in concentration range of 15-35 μg/ml for Nebivolol and 7.5-17.5 μg/ml for S-amlodipine. The method was validated for linearity, range, accuracy, precis...

BACKGROUND This case report describes a patient with chronic unilateral chemosis, likely due to treatment with amlodipine besylate. CASE PRESENTATION A 52-year-old man visited the clinic with symptoms of foreign body sensation and puffiness in his right eye, which had persisted for 4 months. There were no other symptoms, such as itching and pain, in his right eye and no specific symptoms in h...

A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of atorvastatin calcium and amlodipine besylate in their combined dosage forms. The method was based on property of additivity of absorbances. The two wavelengths on amlodipine besylate curve were found out where it showed same absorbance, which were 257.4 and 360.0 nm. At 360.0 ...

BACKGROUND In this study, we investigated the in vitro effects of calcium channel blockers (nifedipine, nitrendipine, isradipine, and amlodipine besylate) on the activity of paraoxonase-1 (PON1). METHODS PON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion-exchange and Sephadex G-200 gel filtration chromatography. RESULTS The calcium channel...

In this paper the procedure for the preparation of inclusion compounds of bioactive substance 2-[(2-aminoetoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylic acid 3-ethyl-5-methyl esterbenzene sulfonate, called amlodipine besylate with β-cyclodextrin (β-CD) and their structural characterization was described. Molecular inclusion compound of amlodipine besylate is obt...

The chromatographic analysis was performed on ODS symmetry C18 column (150 × 4.6 mm, 5 μ particle size) with mobile phase consisting of acetonitrile and phosphate buffer (pH 4.0) in the ratio of 60:40 v/v, at a flow rate of 1.2 mL/min and eluents monitored at 237 nm. The method was validated for linearity, accuracy, precision, robustness and application for assay as per International Conference...

Objective: The present investigation aims to formulate the ideal drug formulation using different surfactants and optimize amlodipine-loaded polymeric nanoparticles. Methods: work was drug-loaded nanoparticles enhance dissolution rate of a poorly water-soluble drug, amlodipine besylate, anti-solvent precipitation method. Characterisation studies include particle size (nm), Zeta potential (mV), ...