The crystal structure of ( E )-doxepin hydrochloride has been solved and refined using synchrotron X-ray powder diffraction data, optimized density functional techniques. crystallizes in space group P 2 1 / a (#14) with = 13.78488(7), b 8.96141(7), c 14.30886(9) Å, ? 96.5409(5)°, V 1756.097(12) Å 3 , Z 4. There is strong discrete hydrogen bond between the protonated nitrogen atom chloride anion...

IMPORTANCE Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations. OBJECTIVE To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population. DESIG...

Anti bacterial activities of several „non-antibiotic drugs‟ used in treatment of a variety of noninfectious human diseases have been observed. Such an effect has been noticed for barbiturates, beta-adrenergic receptor antagonists, diuretic drugs, H1 antihistamines, mucolytic agents, non-steroidal anti-inflammatory drugs, proton pump inhibitors and psychotherapeutic drugs. A synergic or antagoni...

Amitriptyline hydrochloride is a highly permeable active pharmaceutical ingredient (API). The function of these drugs is to block the reuptake of the neurotransmitters, norepinephrine and serotonin in the central nervous system. The nano-sized Amitriptyline (AT) imprinted polymer particles were synthesized successfully. The nanoparticles were characterized by Fourier transform infrared spectros...

Amitriptyline hydrochloride is a highly permeable active pharmaceutical ingredient (API). The function of these drugs is to block the reuptake of the neurotransmitters, norepinephrine and serotonin in the central nervous system. The nano-sized Amitriptyline (AT) imprinted polymer particles were synthesized successfully. The nanoparticles were characterized by Fourier transform infrared spectros...

A sensitive, reproducible and accurate spectrophotometric method has been developed for determining amitriptyline hydrochloride (ATH) from its pharmaceutical formulation based on solvent extraction into chloroform of the product formed with 1, 2-naphthoquinon-4-sulphonate. The reaction and extraction was complete and quantitative at pH 1.3. The Beer’s law of yellow colored species is obeyed in ...

The mixed micellization behaviour of amitriptyline hydrochloride (AMT) with ionic liquid (IL) 1-methyl-3-octylimidazolium hydrochloride, [C8mim][Cl], have been investigated using electrical conductivity, at different temperatures. The non-ideal behaviour (i.e., synergistic interaction) of AMT-[C8mim][Cl] binary mixtures, explained by the deviations in critical micelle concentration (cmc) from i...

BACKGROUND AND OBJECTIVES The antidepressant amitriptyline is used as an adjuvant in the treatment of a variety of chronic pain conditions. This drug interacts with many receptors and ion channels, such as Na+ channels. In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when applied topically in 1...

PURPOSE The purpose of this study was to develop a novel and continuous method for preparing a nanosized particle of drug crystals and to characterize its properties. MATERIALS AND METHODS A new apparatus was introduced to crystallize nanosized drug crystals of amitriptyline hydrochloride as a model drug. The samples were prepared in the pure state by ultrasonic spray, and elaborated depositi...