Eagle (1947a) has shown that p-hydroxybenzyl penicillin (X) was more effective than benzyl penicillin (G) in curing mice infected with Streptococcus pyogenes and Streptococcus pneumoniae. Hewitt and Pittman (1946) have obtained similar results in animals infected with Hemophilus influenzae. It was further shown that penicillin X remains in the blood of human subjects longer than penicillins G o...

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines is devised from easily available 2-aminobenzyl alcohol/2-aminobenzophenones and alkyl/aryl alcohols for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcohols to the corresponding aldehydes/ketones followed by...

Pada penelitian ini dilakukan modifikasi zat warna organik secara komputasi dengan struktur tipe D-A (Donor-Akseptor) dan D-π-A (Donor-π konjugasi-Akseptor). Struktur molekul digambarkan menggunakan software GaussView 6.0.16 dihitung paket Gaussian’16W metode DFT/TDDFT serta basis set B3LYP/6-31G. Zat trifenilamin digunakan sebagai rantai donor yang dimodifikasi cara memvariasikan akseptor. Var...

Two new NHC adducts of cyclopalladated ferrocenylpyrazine complexes 1-2 have been prepared and characterized. An efficient NHC-modulated Pd/Cu cocatalyzed three-component coupling reaction for the synthesis of 2,6-diarylquinolines from aminobenzyl alcohols, aryl ketones, and arylboronic acids in air is described. The reaction involves oxidation, cyclization and Suzuki reactions. The luminescenc...

2-Substituted N-methoxy-9-methyl-9H-purin-6-amines were synthesized either from their corresponding 6-chloro-9-methyl-9H-purines or 2-chloro-N-methoxy-9-methyl9H-purin-6-amine. Great diversity in the amino/imino tautomeric ratios was observed and calculated based on 1H NMR. The tautomers were identified by 1D and 2D 1H, 13C, and 15N NMR techniques, and showed significant variation both in 13C a...

A convenient procedure for the carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates and palladium as the catalyst, the desired products were isolated in moderate to good yields with the installation of two molecules of carbon monoxide. Notably, this is the first example of carbonylative synthesis of batracylin ana...

The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or alpha,beta-unsaturated aldehydes under microwave-assisted conditions constitutes a new synthesis of 2-substituted indoles in high yields (81-97%) in a one-pot reaction. The adduct from indole-4-carboxaldehyde was an advanced intermediate in the synthesis of arcyriacyanin A.