نتایج جستجو برای: amino guanidine
تعداد نتایج: 210030 فیلتر نتایج به سال:
heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. these compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. eight novel 2-amino-4,6-diarylpyrimidine derivatives ...
In previous work in our laboratory, 12 guanidine-resistant (gr) mutants of poliovirus were selected from 12 separate stocks of plaque-purified guanidine-sensitive (gs) viruses (K. Anderson-Sillman, S. Bartal, and D. R. Tershak, J. Virol. 50:922-928, 1984). Peptide mapping of protein 2C and evaluation of virus growth at different temperatures enabled us to subdivide these mutants into several di...
MRL-1237, [1-(4-fluorophenyl)-2-(4-imino-1,4-dihydropyridin-1-yl) methylbenzimidazole hydrochloride], is a potent and selective inhibitor of the replication of enteroviruses. To reveal the target molecule of MRL-1237 in viral replication, we selected spontaneous MRL-1237-resistant poliovirus mutants. Of 15 MRL-1237-resistant mutants obtained, 14 were cross-resistant to guanidine hydrochloride (...
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
IN THE ZWITTERIONIC TITLE COMPOUND (SYSTEMATIC NAME: 4-{[amino(inimio)methyl]amino}benzenesulfonate), C(7)H(9)N(3)O(3)S, the dihedral angle between the plane of the guanidine grouping and the benzene ring system is 44.87 (7)°. The crystal packing is stabilized by inter-molecular N-H⋯O hydrogen bonds involving all the potential donors.
An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities.
Collagen extracted from the diaphyseal region of the tibiae of normal and lathyritic chicks with 0.5 M acetic acid and 5 M guanidine hydrochloride at neutral pH has been studied with regard to chain organization and amino acid composition. Decalcification by dialysis against large quantities of 0.5 M acetic acid and subsequent exposure of the decalcified bones to fresh 0.5 M acetic acid followe...
3-Formyl-4-hydroxyphenylguanidine hydrochloride and its Schiff base copper(II), zinc(II), and iron(III) chelates were synthesized and their inhibitory activity against bovine beta-trypsin were determined. Syntheses of Schiff base metal chelates were carried out from 3-formyl-4-hydroxyphenylguanidine, various L-amino acids, and divalent metal acetate. Their structures were established on the bas...
The synthesis of indolo[2,3-b]quinoline derivatives containing guanidine, amino acid or guanylamino acid substituents as well as their in vitro evaluation for the cytotoxic and antifungal activity are reported. The influence of the guanidine group on the selective cytotoxic and hemolytic properties of indolo[2,3-b]quinoline was investigated. Most of the compounds displayed a high cytotoxic acti...
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