The stability constants of the binary Cu2+ complexes of glycine amide, diglycine, diglycine amide, triglycine, and tetraglycine were determined, as were those of the mixed-ligand Cu2+ systems containing 2,2'-bipyridyl and one of the mentioned oligoglycines. The results evidence that all these complexes have the same structure and, therefore, the binding sites of the ligands have to be the termi...

Two methylene-bridged bis(imidazolium) salts [H4L](PF6)2 and [H4L](PF6)2 with appended amide groups have been synthesized which, after deprotonation, may serve as potentially tetradentate ligands providing two bis(imidazole-2-ylidene) and two amide donors. Using [H4L](PF6)2, a square-planar nickel(II) complex [NiL1] and a six-coordinate bis(ligand) iron(II) complex [Fe(HL)2] have been isolated ...

A novel oxalic amide-linked bisporphyrinate 1has been designed and synthesized, which shows chiral recognition ability for amino acid ethyl esters. The structure of complex 1·(D-Phe-OEt)(L-Phe-OEt) has been solved by X-ray crystallography. It reveals the following information: bisporphyrin unit adopts anti-configuration; compound 1forms 1: 2 complex with amino acid ethyl esters; one important h...

Non-activated alkyl halides are challenging substrates for cross-coupling reactions because they are reluctant to undergo oxidative addition and because metal alkyl intermediates are prone to beta-H elimination. Despite recent progress, well-defined catalysts are rare. We recently prepared Ni complexes with a chelating pincer-type bis(amino)amide ligand. The chloride complex [((Me)NN2)NiCl] is ...

125I-labelled GLP-I(7-36)amide was cross-liked to a specific binding protein in rat lung membranes using disuccinimidyl suberate. A single radio-labelled band at Mr 66,000 was identified by SDS-PAGE after solubilization of the ligand-binding protein complex which is consistent with the presence of a single class of binding sites on rat lung membranes. The band was undetectable when 1 mumol/l GL...

Complex three-dimensional superstructures with useful properties[1] can be created easily by reversibly assembling functionalized small molecules through hydrogen bonding and overlap.[2] Examples are 1a and 1b (Figure 1a), which self-assemble through head-to-tail amide hydrogen bonds into arrays of stacked columns (Figure 1b, c).[3] In these molecules, the dodecyl ether substituents provide a l...

Hyperpigmentation disorders are characterized by an overproduction of melanin. Treatments for pigmentary either disrupt the biosynthesis melanin or cytotoxic to melanocyte. Cysteamine a well-studied depigmenting agent inhibits synthesis at several steps in melanogenesis pathway. It is now through development novel complex combining stabilized cysteamine (st. Cys) with isobionic-amide, forming n...

Derivatives of the fully twisted bicyclic amide 7-hypoquinuclidone are synthesized using a Schmidt-Aubé reaction. Their structures were unambiguously confirmed by X-ray diffraction analysis and extensive spectroscopic characterization. Furthermore, the stability and chemical reactivity of these anti-Bredt amides are investigated. 7-Hypoquinuclidonium tetrafluoroborate is shown to decompose to a...