OBJECTIVE The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors. MATERIAL AND METHOD In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 amel...

Ameloblastomas are tumors of odontogenic epithelium. Although benign, they are quite aggressive, invasive, and at times reach gigantic proportions. Patients with giant ameloblastomas are very rare, but are still encountered in developing countries due to painless growth and patient’s fear of surgery leading to delayed treatment. Management of giant ameloblastomas poses a challenge in terms of a...

transforming growth factor atpha (tgf-a), parathyroid hormone-tike proteins (pthlp) and oncogene p53 proteins have all been demonstrated in a variety of human tumors anil have been implicated as causes of tumor cell aggressiveness. the present study determined the existence of these peptides and their immunohistochemicat profiles in ameloblastomas. odontogenic keratocysts and dentigerous cysts ...

Although ameloblastoma and adenomatoid odontogenic tumor (AOT) belong to the same group according to the World Health Organization, they show different biologic behaviors. PCNA, an amplifier of cell proliferation, and p53, a tumor suppressor protein, are overexpressed in some odontogenic lesions. The purpose of this study was to immunohistochemically evaluate the expression of p53 and PCNA to c...

Aims: The aim of the current study was to detect and compare Human papillomavirus (HPV) in dentigerous cyst and ameloblastoma. Materials and methods: The study included 32 samples, which distributed into dentigerous cysts (n=16) and ameloblastomas (n=16). Conventional PCR assay using SPF1/2 consensus primers and immunohistochemical analysis were performed for the detection of HPV‒DNA and HPV‒L1...

BACKGROUND AND PURPOSE Ameloblastomas and keratocystic odontogenic tumors are major aggressive odontogenic tumors in the maxillomandibular regions, but the differentiation between these 2 tumors is frequently ineffective based on only conventional CT and MR imaging findings. Here, we evaluated diffusion-weighted MR imaging for the differentiation of these 2 odontogenic tumors. MATERIALS AND M...

The aim of this study was to evaluate the immunohistochemical expression of molecules involved in osteoclastogenesis, including the receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in odontogenic keratocysts (OKCs), which has been named as a keratocystic odontogenic tumour by the WHO, and compare their expression with radicular cysts and amelobl...

The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical f...

Objective. To study the pathomorphological structure of ameloblastomas and work out their classification. Materials methods. Histological analysis material obtained after removal jaws in 67 patients was carried out. Results. Pathomorphological classification suggested based on studies Conclusions. The term “ameloblastoma” refers to two groups tumours: true pseudoameloblastomas. Eight structural...

Ameloblastomas are an enigmatic group of oral tumors. The name implies a resemblance to cells of the enamel-forming organ. The general agreement that ameloblastomas are odontogenic in origin occurs largely on the basis of the histologic similarities of the tumor and the developing enamel organ. Ameloblastomas show wide morphological spectra and may pose diagnostic difficulties. Of the many type...