T reatment of large and bulky malignant tumors remains a challenge for oncologists. As tumor size increases the ability of most modalities including conventional external beam radiation to control the tumor decreases. The decrease in normal tissue tolerance with increasing volume of tissue irradiated restricts the escalation of total radiation dose by conventional external beam approaches. Alte...

Surgery and/or radiation were historically standard of care in locally advanced head and neck malignancies. During the 1980s, various radiation schedules were studied. Chemotherapy was eventually added to radiotherapy, first sequentially, as induction chemotherapy, then concurrently, recognizing the primary need of improved locoregional control over that of distant disease control. Simultaneous...

Dividing a dose into a number of fractions spares normal tissues because of repair of SLD between dose fractions and repopulation of cells if the overall time is sufficiently long. At the same time dividing a dose into a number of fractions increases the damage to the tumor because of reoxygenation and reassortment of cells into radiosensitive phases of the cell cycles between dose fractions. T...

AIM To compare the efficacy of two altered fractionation radiotherapy treatment protocols (hyperfractionation and accelerated fractionation with concomitant boost) with conventional fractionation in improvement of locoregional disease control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, or hypopharynx. METHODS From March 1999 to December 2000, 51 patients w...

background: there are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. there are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...

Background: There are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. There are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. Ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...