A Blatter radical-containing polymer backbone is synthesized via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and consecutive ring-opening metathesis polymerization. For this, an alkyne-functionalized radical used for the described CuAAC, yielding a polymerizable derivative of radical. The resulting electrochemically investigated in cyclic voltammetry experiments, paving way possible uti...

The first examples of reactions of Fischer carbene complexes with triynes are reported. The regioselectivity of the reaction of the two different alkyne functions in the symmetrical triyne depends on the nature of the substituent of the triyne. Bis-silyl-substituted triynes react at the central alkyne unit, whereas bis-aryl- and bis-alkyl-substituted triynes react at the end alkyne unit. The re...

A general regioselective rhodium-catalyzed head-to-tail dimerization of terminal alkynes is presented. The presence of a pyridine ligand (py) in a Rh-N-heterocyclic-carbene (NHC) catalytic system not only dramatically switches the chemoselectivity from alkyne cyclotrimerization to dimerization but also enhances the catalytic activity. Several intermediates have been detected in the catalytic pr...

This highlight discusses developments in transition metal-catalysed alkene and alkyne hydroacylation reactions over the past three years. The discussion summarizes the development of new catalyst systems for alkene and alkyne hydroacylation and applications to the synthesis of important ketone building blocks. The highlight captures transition metal-catalysed alkene and alkyne hydroacylation at...

Elastin-like polypeptides (ELPs) functionalized with azide or alkyne groups were produced biosynthetically and coupled via the Cu-catalyzed azide-alkyne cycloaddition to a variety of (bio)molecules.

This highlight discusses developments in transition metal-catalysed alkene and alkyne hydroacylation reactions over the past three years. The discussion summarizes the development of new catalyst systems for alkene and alkyne hydroacylation and applications to the synthesis of important ketone building blocks. The highlight captures transition metal-catalysed alkene and alkyne hydroacylation at...

Cu-catalyzed aerobic oxidative three-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines. The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupling products. Preliminary studies suggest that the reaction pathway involves initial oxidative coupling of the terminal alkyne with the secondary amin...

Here we describe the metathesis reactions of a strained eight-membered ring that contains both alkene and alkyne functionality. We find that the alkyne metathesis catalyst produces polymer through a ring-opening alkyne metathesis reaction that is driven by the strain release from the monomer. The strained monomer provides unusual reactivity with ruthenium-based alkene metathesis catalysts. We i...

Platinum(II) complexes bearing various alkyne-pyrene, alkyne-4'-terpyridine and alkyne-dibutoxyphenylacetylide-terpyridine units were constructed in a step-by-step procedure based on copper-promoted cross-coupling reactions with preconstructed modules; formation of bis(ligand) complexes of Fe(II) and Zn(II) by binding of the pendent terpyridine units provided heterotrinuclear derivatives, all o...