Neurotrophins influence growth and survival of specific populations of neurons through activation of Trks, members of the receptor tyrosine kinase (RTK) family. In this report, we describe the identification and characterization of two substrates of Trk kinases, rAPS and SH2-B, which are closely related Src homolog 2 (SH2) domain-containing signaling molecules. rAPS and SH2-B are substrates of ...

Standalone operation of a wind turbine generating system under fluctuating wind and variable load conditions is a difficult task. Moreover, high reactive power demand makes it more challenging due to the limitation of reactive capability of the wind generating system. A Remote Area Power Supply (RAPS) system consisting of a Permanent Magnet Synchronous Generator (PMSG), hybrid energy storage, a...

Transcription as the key step in gene expression is a highly regulated process. The speed of transcription elongation depends on the underlying gene sequence and varies on a gene by gene basis. The reason for this sequence dependence is not known in detail. Recently, our group studied the cross talk between the nascent RNA and the transcribing RNA polymerase by screening the Escherichia coli ge...

Standalone operation of a wind turbine generating system under fluctuating wind and variable load conditions is a difficult task. Moreover, high reactive power demand makes it more challenging due to the limitation of reactive capability of the wind generating system. A Remote Area Power Supply (RAPS) system consisting of a Permanent Magnet Synchronous Generator (PMSG), hybrid energy storage, a...

OBJECTIVE This study aims to evaluate the performance of Rapid Emergency Medicine Score (REMS), Rapid Acute Physiology Score (RAPS), and Modified Early Warning Score (MEWS) in ascertaining the severity of illness and predicting the mortality of adult hepatic portal venous gas (HPVG) patients presenting to the emergency department (ED). This will assist emergency physicians (EPs) in risk stratif...

Rational Arrival Processes (RAPs) form a general class of stochastic processes which include Markovian Arrival Processes (MAPs) as a subclass. In this paper we study RAPs and their representations of different sizes. We show some transformation methods between different representations and present conditions to evaluate the size of the minimal representation. By using some analogous results fro...

Many successful metaheuristics employ intelligent procedures to obtain high quality solutions for optimization problems. Intelligence emerges in these metaheuristics via memory and learning. Meta-RaPS (Metaheuristic for Randomized Priority Search) which can produce promising solutions is classified as a memoryless metaheuristic. To improve its performance, Q learning and Path Relinking (PR) are...

BACKGROUND The Rapid Acute Physiology Score (RAPS) and Rapid Emergency Medicine Score (REMS) are risk adjustment methods for emergency medical admissions developed for use in audit, research, and clinical practice. Each predicts in hospital mortality using four (RAPS) or six (REMS) variables that can be easily recorded at presentation. We aimed to evaluate the predictive value of REMS, RAPS, an...

INTRODUCTION Oral daclatasvir (DCV; pangenotypic NS5A inhibitor) plus asunaprevir (ASV; NS3 protease inhibitor) is approved in Japan and Korea for treatment of chronic hepatitis C virus (HCV) genotype 1. Response to DCV + ASV is affected by DCV resistance-associated polymorphisms (RAPs) in HCV NS5A. The prevalence and influence of these RAPs on 12-week sustained virologic response (SVR12) to DC...

This paper studies a promising application in Vehicular Cyber-Physical Systems (VCPS) called roadside advertisement dissemination. Its application involves three elements: the drivers in the vehicles, Roadside Access Points (RAPs), and shopkeepers. The shopkeeper wants to attract as many customers as possible by using RAPs to disseminate advertisements to the passing vehicles. Upon receiving an...