نتایج جستجو برای: aldose reductase inhibitors

تعداد نتایج: 226836  

Journal: :iranian journal of basic medical sciences 0
mohammad saadatmandzadeh department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran mohammad rahimizadeh department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran hossein eshghi department of chemistry, school of sciences, ferdowsi university of mashhad, mashhad, iran mojtaba sankian immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran

objective(s):in recent years, the chemistry of tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b]quinolines have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity. as the inhibitor of aldose reductase, the aforementioned compounds may have implication in preventing complications of diabetes. ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
S K Srivastava G A Hair B Das

Aldose reductase (alditol:NADP+ 1-oxidoreductase, EC 1.1.1.21) has been partially purified from human erythrocytes by DEAE-cellulose (DE-52) column chromatography. This enzyme is activated severalfold upon incubation with 10 microM each glucose 6-phosphate, NADPH, and glucose. The activation of the enzyme was confirmed by following the oxidation of NADPH as well as the formation of sorbitol wit...

Journal: :Annals of clinical and laboratory science 1993
S Narayanan

Aldose reductase is a rate limiting enzyme in the polyol pathway associated with the conversion of glucose to sorbitol. The enzyme is located in the eye (cornea, retina, lens), kidney, myelin sheath, and also in other tissues less involved in diabetic complications. Experiments in diabetic animals have implicated sorbitol accumulation in the lens to the development of cataracts. The use of inhi...

Journal: :The Journal of antibiotics 2003
K C Sekhar Rao S Divakar M Srinivas K Naveen Babu N G Karanth A P Sattur

Aldose reductase (EC 1.1.1.21) catalyzes the conversion of glucose to sorbitol and promotes the accumulation of sorbitol in various tissues under the condition of hyperglycemia such as diabetes mellitus. The accumulated intracellular sorbitol causes development of diabetic complications such as cataracts, neuropathy, retinopathy and nephropathy1). Inhibitors of aldose reductase have been shown ...

Journal: :Nucleic acids research 1989
A Graham P J Hedge S J Powell J Riley L Brown A Gammack F Carey A F Markham

The sequence of human foetal liver aldose reductase cDNA obtained from a \-gtlO library 1s presented. This cDNA encodes a protein of 316 ami no adds with a 45 bp 5'-non coding region and a 356 bp 3 1 non coding region. Aldose reductase Is of wide clinical Interest 1n that Inhibitors may prevent the complications associated with diabetes melHtus. The cDNA clone was Identified using ol1gonucleot1...

Journal: :Asia Pacific journal of clinical nutrition 2008
Megha Saraswat P Muthenna P Suryanarayana J Mark Petrash G Bhanuprakash Reddy

Activation of polyol pathway due to increased aldose reductase activity is one of the several mechanisms that have been implicated in the development of various secondary complications of diabetes. Though numerous synthetic aldose reductase inhibitors have been tested, these have not been very successful clinically. Therefore, a number of common plant/ natural products used in Indian culinary h...

Journal: :Diabetes 2006
Wei Sun Peter J Oates James B Coutcher Chiara Gerhardinger Mara Lorenzi

Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains controversial. ARI-809 is a recently discovered aldose reductase inhibitor (ARI) ...

Journal: :The British journal of ophthalmology 1983
M J Crabbe A J Bron C O Peckar M Petchey H H Ting J Howard-Williams

Levels of lens aldose reductase, aldehyde dehydrogenase activity, and erythrocyte NADPH-oxidising (or glyceraldehyde reductase) activity were determined in 17 diabetic and 16 nondiabetic patients undergoing cataract extraction. Lens aldose reductase and aldehyde dehydrogenase activities were significantly lower in diabetics than in nondiabetics. Both enzymes showed significant inverse correlati...

Journal: :General physiology and biophysics 2009
Maria Juskova Vladimir Snirc Alena Gajdosikova Andrej Gajdosik Ludmila Krizanova Milan Stefek

Oxidative stress and polyol pathway hypotheses are generally accepted in the etiology of diabetic complications. Recently, novel carboxymethylated pyridoindoles, structural analogues of the efficient chain-breaking antioxidant stobadine, were designed, synthesised and characterised as prospective aldose reductase inhibitors endowed with antioxidant activity. Of them (2-benzyl-2,3,4,5-tetrahydro...

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