AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti...

GRAS proteins play vital roles in plant growth and development. Physic nut (Jatropha curcas L.) was found to have a total of 48 GRAS family members (JcGRAS), 15 more than those found in Arabidopsis. The JcGRAS genes were divided into 12 subfamilies or 15 ancient monophyletic lineages based on the phylogenetic analysis of GRAS proteins from both flowering and lower plants. The functions of GRAS ...

BACKGROUND Physic nut (Jatropha curcas L.) is an oilseed plant species with high potential utility as a biofuel. Furthermore, following recent sequencing of its genome and the availability of expressed sequence tag (EST) libraries, it is a valuable model plant for studying carbon assimilation in endosperms of oilseed plants. There have been several transcriptomic analyses of developing physic n...

Sir Macfarlane Burnet [1], who is far famed for his pioneer work on cancer surveillance, recommended clearly in his Brailsford Robertson Memorial Lecture that scientists should acquaint themselves with historical antecedents. Therefore, this paper documents such antecedents in respect of the drug treatment modalities used by cancer quacks. Quacks were presented in the 1725 History of Physic by ...

Article history: Seismic and mineral physic Received 24 April 2008 Received in revised form 10 October 2008 Accepted 21 November 2008 Available online 13 January 2009

We assessed the total nitrogen (N) concentrations of 28 still surface water (lake and pond), and 42 flowing surface water (river), monitoring sites under 29 typical terrestrial ecosystems of the Chinese Ecosystem Research Network (CERN) using monitoring data collected between 2004 and 2009. The results showed that the median total N concentrations of still surface water were significantly highe...

In the present paper we describe the model process of an ontologybased expert system for the control of domotic installations and SWRL rules management. From the domotic system database where the attribute values of each device are stored, a background process converts these values into ontology’s instances representing the system physic devices. From these instances, a software application -kn...

b) a personal study of referral diagnoses illustrating the G.P. hospital interface. c) an example of the use of great literature as a teaching tool in small group work (1, 2, 3). He reflected upon a recent visit to centres of excellence and experiment in the USA. i) a look at the fashionable topic of medical problem solving emphasising that hypotheses are often limited and generated early and t...