the effect of daily oral administration of ephedrine (0, 1, 2, 4 or 8 mg kg-1 w0.75) on carcasscharacteristics of forty-four 2 yr old crossbred (mehraban x ghezel) fat-tailed ewes was studied. theewes were fed a fattening ration, and received ephedrine by using a drenching gun for either 50 or 70days. there was a significant interaction (p

in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...

Agonists of ?2-adrenoceptors are increasingly being used for the provision comfort, sedation and management delirium in critically ill patients, with without sepsis. In this context, increased sympathetic inflammatory activity common pathophysiological features linked to multi-organ dysfunction, particularly patients sepsis or those undergoing cardiac surgery requiring cardiopulmonary bypass. E...

Key words ene reaction - kainate receptor agonists Jones’ reagent

Previous studies indicate that organ fibroblasts play an important role in wound healing, collagen production, remodeling processes and pathogenesis of progressive heart, lung, renal and hepatic fibrotic diseases. Several studies suggest a possible inhibitory role for adenosine in the regulation of fibroblast proliferation. The effect of adenosine A2 agonists on proliferation and differentiatio...

Rates of obesity have risen over the past few decades. Subsequently, popularity pharmaceutical weight-loss drug market has grown years to meet growing demand. Among most commonly prescribed drugs for weight management, many are glucagon-like peptide-1 receptor agonists (GLP-1 agonists) which also utilized management type 2 diabetes. There is a substantial and body research comparing efficacy di...

introduction: neuropathic pain can be very difficult to treat and it is one of the important medical challenging about pain treatments. muscimol as a new agonist of gamma-aminobutyric acid receptor type a (gaba a ) have been introduced for pain management. thus, the present study was performed to evaluate the pain alleviating effect of intrathecal injection of different doses of muscimol as gab...

in the present study, the effect of gaba (γ-aminobutyric acid) receptor agonists and antagonists on morphine-induced antinociception was investigated in formalin test in rats. intraperitoneal (i.p.) injection of different doses of morphine (1, 3, 6 and 9 mg/kg) and intracerebroventricular (i.c.v.) injection of different doses of muscimol (0.5, 1 and 2 g/rat) or baclofen (0.25, 0.5 and 1 g/rat) ...

On most adrenergic and cholinergic nerve terminals, prejunctional α-adrenoceptors belonging to the α2-subtype have been identified. Activation of these receptors will decrease the release of norepinephrine. It has been reported that several isolated tissue preparations contain prejunctional dopamine receptors, the stimulation of which inhibits neurotransmission. It has remained uncertain whethe...

Previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor effects of nerve stimulation and administration of α-adrenoceptor agonists were mediated predominantly by α1-adrenoceptors5,9 The present experiments were performed to assess the nature of α-adrenoceptor subtypes within these blood vessels in vivo. Dose/response relationships for adrenaline and noradrenaline pr...