Aggregatibacter actinomycetemcomitans is considered to be a major etiological agent of aggressive periodontitis and includes serotype a to g strains. We herein report the first complete genome sequence of A. actinomycetemcomitans serotype g strain NUM4039. The genome is 2,382,853 bp in length with a G+C content of 44.34%.

We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.

A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.

AIM Different serotypes of Aggregatibacter actinomycetemcomitans have been described based on the lipopolysaccharide (LPS)-O-polysaccharide antigenicity. In turn, a distinct effect of A. actinomycetemcomitans serotypes has been described on cell proliferation and pro-inflammatory cytokine production in different human cells. This study was aimed to investigate the differential dendritic cell (D...

Address correspondence to: 8 John D. Walters 9 College of Dentistry, The Ohio State University 10 305 West 12th Avenue 11 Columbus, OH 43210 12 Telephone: (614) 292-1169 13 Fax: (614) 292-2438 14 email: [email protected] 15 16 Running Title: Azithromycin Kills Intra-epithelial Aggregatibacter 17

Periodontitis adalah peradangan pada jaringan pendukung gigi yang disebabkan oleh kelompok mikroorganisme tertentu salah satunya bakteri Aggregatibacter actinomycetemcomitans, menyebabkan kerusakan ligamen periodontal dan tulang alveolar. Penelitian ini bertujuan untuk membuktikan apakah ekstrak teh putih efektif menghambat pembentukan biofilm actinomycetemcomitans secara in vitro. menggunakan ...