نتایج جستجو برای: aged mice

تعداد نتایج: 583432  

پایان نامه :دانشگاه تربیت معلم - تهران - دانشکده علوم 1391

چکیده آلکالوئیدهای ?– کربولین نظیر هارمان در مواد غذایی گیاهی معمولی( گندم، برنج، ذرت، جو، انگور و قارچ) و در مواد مشتق شده از گیاهانی نظیر توتون یافت می شوند. این آلکالوئیدها دارای اثرات شناختی زیادی از جمله تغییر در حافظه کوتاه مدت و بلند مدت و اثرات توهم زا می باشند. در این مطالعه نقش سیستم گلوتاماترژیک در هیپوکامپ پشتی بر روی اثرات هارمان بر حافظه اجتنابی مهاری مورد مطالعه قرار گرفته است. ...

Background: Doxorubicin, by aggregating in bone marrow, causes genotoxic effects, and thus reduces the repair ability of cells. The present study was conducted as an in vitro evaluation of age effects on the cytotoxicity induced by doxorubicin in mesenchymal stem cells (MSCs).    Methods: The MSCs of female BALB/c mice aged 1, 8, and 16 months were separated, characterized, and subse...

Journal: :Journal of Vascular Research 2021

This study tested the hypothesis that endothelium-specific GTP cyclohydrolase I (GTPCH I) overexpression (Tg-GCH) restores age-associated endothelial dysfunction in vivo. Aortic GTPCH expression and serum nitric oxide (NO) release were measured young aged mice. rings from wild-type (WT) mice Tg-GCH suspended for isometric tension recording. A hind limb ischemia model was used to measure blood f...

Journal: :BMC Musculoskeletal Disorders 2021

Abstract Background The angiotensin-converting enzyme 2 (ACE2)/angiotensin 1–7 (Ang-(1–7)) axis has been shown to protect against the age-associated decline in skeletal muscle function. Here, we investigated protective effects of ACE2 mitigating function and identify potential underlying molecular mechanisms. Methods We measured expression levels Ang-(1–7) C57BL/6J mice different ages correlate...

Journal: :international journal of reproductive biomedicine 0
shabnam mohammadi mehdi jalali mohammad reza nikravesh alireza fazel alireza ebrahimzadeh mehran gholamin

background: catsper genes are a novel family of four sperm-specific calcium channels, which indicate testis-specific expression patterns. despite the crucial role of catsper genes in the male reproduction, very little is known about the factors that regulate their expression. objective: the objective of this study was to investigate the effects of vitamin e treatment on the expression of catspe...

Abdolhossein Shahverdi, Hossein Baharvand Mansoureh Movahedin, Mojtaba Rezazadeh Valojerdi

Background To assess embryos derived by the transfer of meiosis-II chromosomes (M-II-t) from aged mice oocytes into ooplasms from younger mice to overcome the problem of age-related decline in female fertility. MaterialsAndMethods The developmental capacity karyotype and ultrastructure of reconstructed oocytes derived from meiosis-II chromosome transplantation from aged mice into the ooplasms o...

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