Aerodynamic lens inlets have revolutionized aerosol mass spectrometry by allowing the introduction of a very narrow particle beam into a vacuum chamber for subsequent analysis. The real-time measurement of particle beam width after an aerodynamic lens is of interest for two reasons: (1) it allows a correction to be made to the measured particle concentration if the beam is so broad, due to poor...

As a sequel to our previous effort on the modeling of particle motion through a single lens or nozzle, flows of gas–particle suspensions through an integrated aerodynamic-lens–nozzle inlet have been investigated numerically. It is found that the inlet transmission efficiency (ηt) is unity for particles of intermediate diameters (Dp ∼ 30–500 nm). The transmission efficiency gradually diminishes ...

High sampling efficiencies of analyte ions, molecules or particles are needed to maximize the sensitivity of mass spectrometers. “Ion funnels”, hich utilize electrodynamic focusing, have been shown to effectively focus ions with mass-to-charge ratio (m/z) ranging from ∼100 to 5000. ocusing efficiencies of ion funnels drop for higher m/z values because very high voltages are needed to overcome t...

The Laser-Induced Breakdown Detection technique (LIBD) was adapted to achieve fast in-situ characterization of nanoparticle beams focused under vacuum by an aerodynamic lens. The method employs a tightly focused, 21 μm, scanning laser microprobe which generates a local plasma induced by the laser interaction with a single particle. A counting mode optical detection allows the achievement of 2D ...

this work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. in-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

A nozzle conŽ guration for the production of an intense and collimated supersonic cluster beam is presented and characterized by numerical modeling. A simple lens added to a cylindrical nozzle exploits aerodynamic focusing effects. The effect of the focalizing nozzle is an enrichment of the core of the jet with clusters of an arbitrary size interval depending on carrier gas pressure and tempera...

in view of the rapid expansion of contact lens amongst the users, new dimensions have been added to the domain of ophthalmology: giant papillay conjunctivitis, a disease caused by different kinds of contact lens, appears weeks or months after they are used, although some patients are struck years later. the predominant symptoms are increased awareness of lenses, ocular itching, blurred vision a...

A novel aerodynamic lens-based inlet system was developed for a wide particle size range, and it could extend the range of transmitted particulate matter (PM) to 50 nm–10 ?m. The lens adopted seven-stage focusing orifice PM, relaxation with virtual impact function introduced at front lens. Through innovative design, concentrate input samples as well effectively enhance effect on large PM. Furth...