beta-2 adrenoceptors in blood vessels are one of the active factors that play a role in regulation of tissue blood flow. in diabetic angiopathy, responsiveness of these receptors is decreased, while that is increased in inflammation. according to these opposite effects, the aim of this study was to investigate the vasodilatory response of knee joint blood vessels to salbutamol (beta-2 adrenocep...

Carp were cannulated in the dorsal aorta, and after 2 days of recovery they were infused with 1) norepinephrine, 2) yohimbine (alpha(2)-antagonist) plus norepinephrine, 3) clonidine (alpha(2)-agonist), and 4) isoproterenol (nonselective beta-agonist). Norepinephrine lowered the plasma free fatty acid (FFA) level and raised the plasma glucose level for several hours. Norepinephrine in combinatio...

Five adrenoceptor subtypes are involved in the adrenergic regulation of white and brown fat cell function. The effects on cAMP production and cAMP-related cellular responses are mediated through the control of adenylyl cyclase activity by the stimulatory beta 1-, beta 2-, and beta 3-adrenergic receptors and the inhibitory alpha 2-adrenoceptors. Activation of alpha 1-adrenoceptors stimulates pho...

Short-term (5 days) administration of L-thyroxine (0.1 mg/kg i.p. daily) to adult SpragueDawley rats induces a modest degree of cardiac hypertrophy (22% increase in heart weight/body weight ratios) and directionally opposite changes in cardiac adrenoceptors (24% increase in fi-adrenoceptors and 201% decline in ae-adrenoceptors). Pretreatment with colchicine did not affect the ability of L-thyro...

The relative importance of the different α1-adrenoceptor subtypes in regulation of peripheral resistance and systemic arterial blood pressure is not clear, as the contribution of different subtypes to vasoconstriction varies with species and resistance vascular bed [1,2]. A further factor which may influence the subtypes involved in vasoconstriction physiologically is the manner of receptor act...

Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...

Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...

transcutaneous electrical nerve stimulation (tens) is an analgesia inducing method with increasing applications in clinical procedures. in this study we tried to evaluate the role of the adrenergic system and its different adrenoceptor subtypes in tens-induced analgesia. two types of low and high frequency electrical stimuli were used in rats through needle electrodes, inserted at the base of t...

Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...