Previously published papers have been reproduced with permission from the copyright holders. ….we don´t always remember that we forgot, so that to remember that we forgot is not exactly forgetting, is it? What I loved by Siri Hustvedt SUMMARY Neuropsychological Functions in Relation to Structural and Functional Brain Changes in Alzheimer's Disease. The aim of this doctoral thesis was to study n...

BACKGROUND Psychological stress is known to affect the immune system. The Limbic Hypothalamic Pituitary Adrenal (LHPA) axis has been identified as the principal path of the bidirectional communication between the immune system and the central nervous system with significant psychological activators. Personality traits acted as moderators of the relationship between life conflicts and psychologi...

Recent findings in epigenetics shed new light on the regulation of gene expression in the central nervous system (CNS) during stress. The most frequently studied epigenetic mechanisms are DNA methylation, histone modifications and microRNA activity. These mechanisms stably determine cell phenotype but can also be responsible for dynamic molecular adaptations of the CNS to stressors. The limbic-...

recognized as a reliable tool for assessing the hypothalamus-pituitary-adrenal (hpa) axis, measurement of salivary cortisol plays an important role in both the clinical and research settings. to establish a normative data, which forms the basis for the usage of this valuable parameter, we gathered 8:00 h saliva samples from 94 healthy individuals aged 6-14 years. cortisol levels were measured b...

Introduction: Glucocorticoids are considered the cornerstone of the induction phase in all treatment protocols of acute lymphoblastic leukemia (ALL). Among the adverse effects of high-dose glucocorticoid treatment, adrenal insufficiency is secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This drawback of exogenous steroid therapy gains a contemporary particular relevan...

results all variables reached a peak at 1 minute post-jump. salivary alpha-amylase, galvanic skin responses and heart rate did not return to basal value at 90 minutes post-jump, while cortisol returned to basal value at 90 minutes post-jump. conclusions this evidence indicates that parachute jumping is accompanied by a dissociation of sns and hpa response patterns in novice parachutists, showin...

This study investigated adrenocortical activity in response to different challenging and positive affect emotional contexts in child-mother dyads, as function of attachment security (children's secure base behaviors and mothers' attachment representations). Fifty-one children ranging in age from 18 to 26 months and their mothers participated in this study. Secure children showed significant inc...