Zellweger spectrum disorders are a group of autosomal recessive disorders characterized by impaired peroxisome functions. The clinical spectrum is broad, ranging from the classical most severe Zellweger syndrome to patients with a relatively mild phenotype. Treatment options are limited to symptomatic and supportive therapy. During routine follow-up we discovered patients with asymptomatic prim...

PURPOSE To assess the cognitive and sexual/hormonal functioning of prostate cancer patients treated with a luteinizing hormone-releasing hormone (LH-RH) agonist, and the relationships thereof with adrenal and residual testicular androgen levels. MATERIALS AND METHODS Previously, we reported the effect of a luteinizing hormone-releasing hormone (LH-RH) agonist on testicular and adrenal androge...

Objective: Detection and evaluation of adrenal glands are complex problems in conventional ultrasonography in dogs. Using three-dimensional (3D) ultrasonography (US) in adrenal gland volume evaluation can add new potential for further adrenal studies. Design: Descriptive study Animals: a total of 10 mix breed dogs Procedures: The dogs underwent two dimensional (2D) and 3D US of the adrenal g...

The adrenal gland is an essential endocrine organ for the stress response. The functions of this organ may be studied by ligation of the adrenal artery or adrenalectomy. However, in prior studies, descriptions of the anatomical variations of the adrenal artery were insufficient and inconsistent. Therefore, anatomical variations of the arterial supply to the adrenal gland were studied in 18 male...

The adrenal cortex tumors include both malignant adrenal cortex cancers (ACC) and benign masses (ACT) that can be either secreting, of one of the hormones normally produced in the adrenal cortex (Cushing’s syndrome if the hypersecretion is of cortisol or Conn’s syndrome if it is aldosterone) or non-secretory (Incidentalomas). The outer part of the adrenal glands, the adrenal cortex, is responsi...

The nuclear receptor steroidogenic factor 1 (SF-1) is essential for adrenal development and steroidogenesis. The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes. Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances. Indeed, we found that D...