As the amount of sewage sludge (SS) is increasing worldwide, anaerobic digesters (ADP) are being distributed to reduce it and treat in an environmentally friendly way. In Korea, 20 years have passed since introduction ADP, but number treatment plants (STP) installed with ADP only about 10% total STP. Accordingly, problems improvements were examined through material flow analysis targeting STP, ...

There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical cell biological methods potential presence polymerase-1 these organelles. Our show that endogenous overexpressed poly(ADP-ribose)polymerase 1 is only localized to nucleus a clear exclusion cytosolic co...

Abstract Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors initiate repair. Serine is the major residue for ADP-ribosylation upon damage, which strictly depends on HPF1. Here, we report crystal structures of human HPF1/PARP1-CAT ?HD complex at 1.98 Å resolution, mouse HPF1 1.71 1.57 respectively. Our mutagenesis data confirm that structur...

Post-translational modification (PTM) with ADP-ribose and poly(ADP-ribose) using nicotinamide adenine dinucleotide (NAD+) as substrate is involved in the regulation of numerous cellular pathways eukaryotes, notably response to DNA damage caused by stress. Nevertheless, due intrinsic properties NAD+ e.g., high polarity associated poor cell passage, these PTMs are difficult characterize cells. He...

The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from islets Langerhans. Glucose-stimulated insulin (GSIS) by pancreatic β -cell is main mechanism for reducing elevated plasma glucose. Here we present systematic modeling workflow development kinetic pathway models using Systems Biology Markup Language (SBML). Steps include retrieval informa...

Abstract We study the problem of scheduling container transport in synchromodal networks considering stochastic demand. In networks, transportation modes can be selected dynamically given actual circumstances and performance is measured over entire network time. model this as a Markov Decision Process propose heuristic solution based on Approximate Dynamic Programming (ADP). Due to multi-period...

Objective: Assess the agreement and validity between relative body fat percentages estimated using anthropometric measurements air displacement plethysmography (ADP). Methods: A cross-sectional study was conducted on 118 adolescents (60 females) aged 10 to 14 years (x̄=12.19, sd=1.18). Adolescents were classified as eutrophic or with overweight according mass index (body weight/height2) (x̄=20,12...