Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant cancer syndrome, results from germ line mutation or deletion of the Adenomatous Polyposis Coli (APC) gene on chromosome 5q21. Patients with FAP suffer from multiple polyps mainly at the colorectal region as well as other parts of the gastrointestinal tract, which has propensity to transform into carcinoma. FAP has also...

Background: Colorectal cancer is the second most common cancer in the world which is mainly caused by epigenetic and environmental factors. Among these epigenetic factors, gut microbiota is an important one. Although it has not been proved a unique group of bacteria correlated with colorectal cancer, these findings have generally demonstrated differences between healthy and disease gut microbio...

BACKGROUND Deep vein thrombosis is an important cause of morbidity and mortality. However, its association with adenomatous polyposis coli is extremely rare. Here we present an interesting case of deep vein thrombosis associated with adenomatous polyposis coli. CASE PRESENTATION A 15 year old female who was having fever and diarrhea for 5 months developed bilateral asymmetric painful swelling...

Fundic gland polyps (FGPs) are the most common type of gastric polyps (up to 50%). They are found in up to 0.8-1.9 % of the general population, and in 40-84 % of the patients suffering from familial polyposis syndromes. They might be sporadic or associated to polyposis syndromes. When the former, they should be considered exclusively benign lesions, and possibly related to the chronic use of pr...

The other mode of treating these patients are subtotal colectomy with ileorectal anastomosis alongwith regular follow up with proctoscopy for development of cancer in retained rectal mucosa(3,7). Recently, Stevan et al. (8) utilized laproscope for total proctocolectomy as well as ileoanal anostomosis while others performed ileopouch anal anastomosis alongwith total proctocolectomy(9,10). Thus t...

Background:. UK Clinical Molecular Genetics Society (CMGS) consensus best practice guidelines for molecular analysis of familial adenomatous polyposis coli (FAP) were published in 2000. Technological developments in molecular testing for FAP together with the clinical and molecular characterisation of MUTYH-associated polyposis (MAP) led to the need to update the original FAP guidelines which w...