Dimova E., Chankova S. & Bryant P. E. (2008): Some results on the contribution of DSB DNA rejoining for the development of adaptive response in Chlamydomonas reinhardtii. Proceedings of the III Congress of Ecologists of the Republic of Macedonia with International Participation, 06-09.10.2007, Struga. Special issues of Macedonian Ecological Society, Vol. 8, Skopje. The “adaptive response” (AR) ...

When several experimental treatments are available for testing, multi-arm trials provide gains in efficiency over separate trials. Including interim analyses allows the investigator to effectively use the data gathered during the trial. Bayesian adaptive randomization (AR) and multi-arm multi-stage (MAMS) designs are two distinct methods that use patient outcomes to improve the efficiency and e...

To observe the adaptive response (AR) induced by ionizing radiation in human fibroblasts under monolayer and 3-dimensional (3-D) condition. Three kinds of fibroblasts were cultured under both monolayer and 3-D condition. Immunofluorescent staining was used to detect the γ-H2AX foci and the morphological texture. Trypan blue staining was used to detect the cell death. Western blot was used to de...

The adaptive response (AR) is a phenomenon by which cells exposure to sublethal doses of DNA-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (CT), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (CR). The adaptive response (AR) induced by radiation in human lymphocyte...

We examine three variations of the regularization methods for response-adaptive randomization (RAR) and compare their operating characteristics. A power transformation (PT) is applied to refine the randomization probability. The clip method is used to bound the randomization probability within specified limits. A burn-in period of equal randomization (ER) can be added before adaptive randomizat...

Regular exercise is beneficial to cardiovascular health. We tested whether mild voluntary exercise training modifies key myocardial parameters [ventricular mass, intracellular calcium ([Ca2+]i) handling and the response to beta-adrenoceptor (beta-AR) stimulation] in a manner distinct from that reported for beneficial, intensive training and pathological hypertrophic stimuli. Female rats perform...

BACKGROUND Diagnosis and management of depression occurs frequently in the primary care setting. Current diagnostic and management of treatment practices across clinical populations focus on eliminating signs and symptoms of depression. However, there is debate that some interventions may pathologize normal, adaptive responses to stressors. Analytical rumination (AR) is an example of an adaptiv...

background: whether exposure to common electromagnetic fields affects human health adversely has been a controversial issue. the main goal of this study was to assess the role of 900 mhz microwave radiations with different specific absorption rates (sars), emitted from some widely used cell phones, on the induction of adaptive response in male balb/c mice after receiving a lethal dose of gamma ...

conclusions these findings suggest that exposure to tc-99m could induce a radio-adaptive response against the exposure of tl-201. background low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. this phenomenon is known as radio-adaptive response. the aim of this study was to investigate the percentage...

background: in some areas of ramsar, a city in northern iran, residents receive a much higher annual radiation exposure than is permitted for radiation workers. induction of adaptive response in residents of ramsar has been reported previously. in this study induction of such a response in short term exposure to high background levels of gamma radiation is investigated. materials and methods: f...