the traditions transmitted from the infallible imams (a. s.) are one of the most important resources of jurisprudential rulings. there are some conditions for any tradition to be accepted and islamic scholars have identified several ways for investigating that whither the conditions are met in a given tradition or not. some of these conditions are related to the narrators of a tradition, such a...

OBJECTIVES To examine the risk of bowel obstruction in older adults during treatment with extended-release nifedipine compared with patients treated with amlodipine. DESIGN Retrospective cohort study using multiple linked healthcare databases. SETTING Ontario, Canada from 1 April 1997 to 31 December 2010. PARTICIPANTS We identified patients aged 66 years and older who started treatment wi...

The aim of the present study was to minimize the unwanted toxic effects of Diltiazem Hydrochloride (DTZ) by kinetic control of drug release. DTZ was incorporated into the biocompatible and biopolymer blends of chitosan (CH) and micro crystalline cellulose (MCC) matrix pellets using pelletization technique. Solid, free flowing matrix pellets and yields up to 97.5 %. More than 98 % of the isolate...

The aim of this study was to evaluate the monolithic osmotic tablet system (MOTS) containing a solid dispersion with the practically water-insoluble drug nifedipine in vitro and in vivo. In the drug release study in vitro, the release profiles of this system had almost zero-order kinetics. The influences of tablet formulation variables, sizes of the delivery orifice, membrane variables, and val...

The aim of the present study was to prepare matrix pellets loaded nifedipine (NF) as model drug by pellitization technique by using blend of gelucire 50/13 (GL) and glyceryl palmito stearate (GPS) as hydrophilic and hydrophobic carriers in different concentrations. This system was able to prolong the drug release, minimizing the drug related adverse effects and improve bioavailability in differ...

The agents commonly called the calcium channel blockers comprise an increasing number of agents, including the prototypical verapamil (Calan, Isoptin), nifedipine (Adalat, Procardia), and diltiazem (Cardizem). These agents are a chemically and pharmacologically heterogeneous group of synthetic drugs, but they possess the common property of selectively antagonizing Ca movements that underlie the...

A 55-year-old man was referred to us because of renal dysfunction (serum creatinine 1.82 mg/dL). Three years earlier, he had aortic dissection associated with left renal artery occlusion and had undergone surgery for ascending aorta and aortic arch replacement. He had been receiving the following medications for 3 years; nifedipine (Adalat-CR) 40 mg, carvedilol 10 mg, aspirin 100 mg, allopurino...