Ferritin is a positive acute phase reactant, exhibiting increased levels in blood during the acute phase response. Nevertheless, the precise role of ferritin as an acute phase reactant remains to be clarified. As for other acute phase proteins, ferritin is produced and secreted by hepatocytes. However, ferritin is also produced and secreted by other cell types, including macrophages and cancer ...

A59-year-oldmanwith a history of shoulder and knee pain presented to our clinic reporting 6 years of left osteoarthritic hippain.Hispainhadbeenprogressive, and at the timeofpresentation,he required theuseofacane for support. The results of radiologic studies showed a loss of joint space with thinning of the upper aspect of the lefthip jointwithbone-on-boneappearanceandsubchondral cyst formation...

A single intraperitoneal injection of bacterial lipopolysaccharide (LPS) or its lipid A component induced high levels of glycoprotein, gp70, in sera of several strains of mice within 24 h. This serum gp70 response induced by LPS was independent of the activation of B cells and the presence of T cells. However, serological and immunohistochemical studies demonstrated the production of gp70 by he...

mean concentration of 0.63 mmol/L, is a powerful acute phase reactant as it changes dramatically during vascular injury and inflammatory processes5. Albumin acts as a buffering agent for endogenous or exogenous toxic molecules due to its various ligands binding ability4,5. The biochemical mechanisms modifying the amino-terminal region of albumin during ischemia are unclear, but reperfusion afte...

C-reactive protein and four other acute phase reactant proteins of non-cardiac, origin (orosomucoid, alpha 1- antitrypsin, heptoglobin, and alpha 2- macroglobulin) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction. A similar comparison was made in 57 patients undergoing surgery and 72 patients with acute infection. C-reactive protein wa...