The aim of this study was to evaluate the toxicology safety of a genetically modified (GM) Bacillus thuringiensis with vegetative insecticidal protein (VIP) gene. Acute and subacute toxicity studies by using its powder preparation were conducted in Wistar rats. The result of the acute study showed the no-observable-adverse-effect level (NOAEL) of this GM B. thuringiensis powder preparation was ...

The use of engineered nanoparticles in food and pharmaceuticals is expected to increase, but the impact of chronic oral exposure to nanoparticles on human health remains unknown. Here, we show that chronic and acute oral exposure to polystyrene nanoparticles can influence iron uptake and iron transport in an in vitro model of the intestinal epithelium and an in vivo chicken intestinal loop mode...

In the editorial by Dr. Reza Afshari “Empowerment of Medical Toxicology in Asia Pacific Region” published in the Asia Pacific Journal of Medical Toxicology (APJMT) (1), the role of Asia Pacific Association of Medical Toxicology (APAMT) in promoting medical toxicology has been discussed and some suggestions have been made regarding how to promote this field of medical sciences in the region. The...

Objectives: This work aimed to evaluate the acute and chronic toxicity of ethanolic extract Abelmoschus esculentus, administered orally Swiss albino mice. Methods: An dosage 2000 mg/kg was administrated studies were conducted following organization for economic cooperation development guidelines 425 407 respectively in During study, general signs monitored. The mice which are used toxicology st...

Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasi...

423 A k-NN Algorithm for Predicting Oral Sub-Chronic Toxicity in the Rat Domenico Gadaleta 1,2, Fabiola Pizzo 1, Anna Lombardo 1, Angelo Carotti 2, Sylvia E. Escher 3, Orazio Nicolotti 2 and Emilio Benfenati 1 laboratory of environmental Chemistry and toxicology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; Dipartimento di Farmacia − Scienze del Farmaco, Università degl...

a 19-year-old woman was referred to the emergency surgery department with severe abdominal pain, icterus, and anemia. the patient’s clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (bll), which was 41/5 µg/dl. therefore toxicology consult was performed to treat lead toxicity. recheck of the bll showed the level as 53/7...

A recombinant lactase was expressed in Pichia pastoris, resulting in enzymatic activity of 3600 U/mL in a 5 L fermenter. The lactase product was subjected to a series of toxicological tests to determine its safety for use as an enzyme preparation in the dairy industry. This recombinant lactase had the highest activity of all recombinant strains reported thus far. Acute oral toxicity, mutagenici...