recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

adipose tissue secretes a large number of adipocytokines such as leptin, resistin, and adiponectin. many of these hormones and cytokines are altered in obese individuals and may lead to disruption of the normal balance between cell proliferation, differentiation, and apoptosis. the aim of our work was to investigate the disturbance of secretion of adiponectin and resistin in de novo and relapse...

acute lymphoblastic leukemia (all) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. twenty patients with all, who had been referred to the children's medical center hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic pr...

introduction : acute lymphoblastic leukemia (all) and non-hodgkin's lymphoma (nhl) are the most common malignancies in children and adolescents. therapies such as corticosteroids, cytotoxic and radiotherapy will have harmful effect on bone mineral density (bmd) which can lead to increased possibility of osteoporosis and pathological fractures. subjects and methods: this 3-year cross-sectional s...

abstract background leukemia is the most prevalent childhood cancer and acute lymphoblastic leukemia (all) constitutes 75% of all cases. the most frequent presenting symptoms are fever, weight loss and pallor. early detection of clinical symptoms positively affects timely diagnosis. the objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phen...

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hypercalcemia in children is a medical emergency and often manifests as nonspecific symptoms such as nausea, vomiting, weight loss, and anorexia. severe hypercalcemia is a rare complication of malignancy in children, while it can be seen in various types of malignant tumors. it is usually associated with significant morbidity and may be severe enough to threaten life. incidence of hypercalcemia...

introduction: acute leukemia is the most common malignancy in children and acute lymphoblastic leukemia (all) accounts for 75% of acute leukemia cases. new treatment protocols have resulted in complete remission rates up to nearly 100% in children with acute lymphoblastic leukemia. today, one of the most important prognostic factors in acute lymphoblastic leukemia is intensity of the treatment....

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...

Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...