Ferrous fumarate Pustular drug eruption Acute generalized exanthematous pustulosis Generalized pustular psoriasis Aoi Iti, MD, Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036 (Japan) Although ferrous agents are commonly used clinically, they rarely induce allergic skin eruptions. Moreover, drug eruptions of the pustular type are uncommon and include ...

Sir, Terbinafine is the most common antimycotic agent that can result in acute generalized exanthematous pustulosis (AGEP). The clinical features, laboratory findings and histopathology of AGEP are now well described. How­ ever the optimum management of this condition has not been agreed. We read with interest the recent case described by Beltraminelli et al. (1) and would like to report a furt...

Figure 1. Epidemiologic curve of a hand-foot-and-mouth disease outbreak in a Thai hospital nursery. 11. Saissi EH, Beau-Salinas F, Jonville-Bera AP, Lorette G, Autret-Leca E. Drugs associated with acute generalized exanthematic pustulosis (in French). Ann Dermatol Venereol 2003; 130:612–8. 12. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (...

Acute generalized exanthematous pustulosis (AGEP) is a rare inflammatory dermatosis characterized by multiple nonfollicular pustules that occur on erythematous skin. Despite its similarity to pustular psoriasis and association with fever and leukocytosis, AGEP typically heals quickly. Etiologically, drugs and viruses have been suspected in most cases. Here, we present a case of AGEP, in a woman...

BACKGROUND Patch tests are considered safe but adverse reactions have been reported. OBSERVATIONS A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described. Of special interest are the negative patch test results obtained with the offending drug. The case is discussed against the background of the putative mechanisms of AGEP and the r...

Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction caused mostly by medication. Early diagnosis is important as initiation of supportive treatment and avoidance of drug is of prime importance. A young male presented with an erythematous rash after taking diclofenac for pain. Polarized dermoscopy revealed milky globules on a uniform reddish background s...

Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by multiple small, sterile, non-follicular pustules on an erythematous and edematous base, usually accompanied by fever and neutrophilia. It is attributed to systemic drugs in over 90% of cases, mainly β-lactam and macrolide antimicrobials. Viral infections, mercury exposure, Ginkgo biloba, and spider ...

Acute generalized exanthematous pustulosis (AGEP) is a skin eruption that is primarily drug induced and characterized by the formation of numerous acute and sterile pustules on an erythematous background as mentioned by Weinblatt et al. (1999). We present a case of AGEP, following administration of etanercept, an antitumour necrosis factor alpha (TNF- α ) antibody, in a patient with psoriasis. ...

Anti-malarial drugs may induce numerous cutaneous adverse drug reactions as well as exacerbation of psoriasis. Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and is characterized by acute, extensive formation of non-follicular sterile pustules on an erythematous and oedematous substrate. Hydroxychloroquine (HCQ), an anti-malaria...

Acute generalized exanthematous pustulosis (AGEP) is a rare but well-known cutaneous reaction pattern mostly caused by drugs, i.e. aminopenicillins. Fever and erythema, followed by numerous tiny non-follicular pustules that usually appear within days after administering the medication, are characteristic. The reaction is self-limiting once the causative drug is withdrawn. The pathomechanisms of...