objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...

Tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a type II transmembrane protein, belongs to the TNF superfamily. Compared to other family members, TRAIL is a promising anti-cancer agent that can selectively induce apoptosis of various types of transformed cells and xenografts, with negligible cytotoxicity against normal tissues. Ophiopogonin B is a bioactive ingredient of Radix...

The synthesis of activated carbon derived from water hyacinth has been successfully carried out as an iron adsorbent in a laboratory-scale filter design system. In this article, is made through carbonization process at 400°C and 500°C with NaOH activating agent. This acts media for purifying well by assessing the flux, pH removal efficiency before after filtration. results showed that use tempe...

multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

Ion channels in tonoplast of leaf cells of a Crassulacean acid metabolism plant, Graptopetalum paraguayense, using the patch clamp technique were investigated. Results showed the existence of two types of channels involved in the malate ion transport across the tonoplast. One type corresponded to the slow-activating vacuolar-type (R Hedrich, E Neher [1987] Nature 329: 833-836), probably taking ...

BACKGROUND Increases in plasma anaphylatoxins frequently are used as an index of haemodialysis membrane biocompatibility; however, their plasma levels may be influenced by the loss of anaphylatoxins into the dialysate compartment. METHODS We compared the generation and compartmental distribution of anaphylatoxins, C3a and C5a, in a high flux and a low flux polysulfone membrane dialyser when w...

The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selectively in retinal cells. This mutant induces defective endocytic recycling of transferrin receptor ...

introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

In this paper, a novel variable-leakage-flux interior permanent magnet (VLF-IPM) motor is proposed, which kind of mechanical flux-adjusting PM motor. The VLF-IPM can obtain the advantages IPM and overcome difficulty to adjust airgap flux by locating self-activating device that introduced in paper on rotor. effect barriers leakage circuit analysed establishing rotor parametric model clarify infl...