objective: the passage of ionizing radiation in living cells creates clusters of damaged nucleotides in dna. in this study, dna strand breaks induced by the beta particle of iodine-131 (i-131), have been determined experimentally and compared to monte carlo simulation results as a theoretical method of determining131i damage. materials and methods: in this experimental study, in order to create...

background: monte carlo (mc) modeling of a linear accelerator is a prerequisite for monte carlo dose calculations in external beam radiotherapy. in this study, a simple and efficient model was developed for elekta sl-25 linear accelerator using mcnp4c monte carlo code materials and methods: the head of elekta sl-25 linac was simulated for 6 and 18 mv photon beams using mcnp4c mc code. energy sp...

Background: Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers.Objective: The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and ...

background: high-velocity carbon ion beams represent the most advanced tool for radiotherapy of deep-seated tumors. currently, the superiority of carbon ion therapy is more prominent on lung cancer or hepatomas. materials and methods: the data for lateral straggling and projected range of monoenergetic 290 mev/u (3.48 gev) carbon ions in muscle tissue were obtained from the stopping and range o...

background: the presence of a wedge filter in the beam trajectory can modify the beam quality and cause some changes in the dosimetry parameters which are usually difficult to be measured directly and accurately. material and methods: in this study the mcnp-4c monte carlo code was used to simulate the 9 mv photon beam generated by a linear accelerator. upon getting a good agreement between the ...

Introduction: Secondary radiation such as photoelectrons, Auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external X-ray beam after being loaded with elements capable of activating the tumor, e.g.; I and Gd. Materials and Methods:  In this investigation, the MCNPX code was used for simulation and calculation of dose enhancement facto...

Background: Iodine brachytherapy sources with low photon energies have been widely used in treating cancerous tumors. Dosimetric parameters of brachytherapy sources should be determined according to AAPM TG-43U1 recommendations before clinical use. Monte Carlo codes are reliable tools in calculation of these parameters for brachytherapy sources. Materials and Methods: Dosimetric param...

abstract background: accurate methods of radiation therapy dose calculation. there are different monte carlo codesfor simulation of photons, electrons and the coupled transport of electrons and photons. mcnpis a general purpose monte carlo code that can be used for electron, photon and coupledphoton-electron transport.monte carlo simulation of radiation transport is considered to be one of the ...

introduction: in brachytherapy, radioactive sources are placed close to the tumor, therefore, small changes in their positions can cause large changes in the dose distribution. this emphasizes the need for computerized treatment planning. the usual method for treatment planning of cervix brachytherapy uses conventional radiographs in the manchester system. nowadays, because of their advantages ...