RATIONALE In heart, Ca(2+) entering myocytes via Ca(V)1.2 channels controls essential functions, including excitation-contraction coupling, action potential duration, and gene expression. RGK GTPases (Rad/Rem/Rem2/Gem/Kir sub-family of Ras-like GTPases) potently inhibit Ca(V)1.2 channels, an effect that may figure prominently in cardiac Ca(2+) homeostasis under physiological and disease conditi...

Action of the uppermost medial internal intercostal muscles-the parasternals-during rapid eye movement (REM) is uncertain; no direct recordings exist of shortening of these muscles during sleep. Historically, motor inhibition of skeletal muscles during REM sleep is thought to cause global loss of chest wall muscle function, REM "atonia," with preservation of only diaphragm function. However, re...

Previous investigations have shown that REM sleep deprived (REM SD) rats display an enhanced response to dopamine agonists. This action seems to be mediated through a supersensitivity of dopamine post-synaptic receptors. Accordingly, REM SD was performed on rats with an experimental model of Parkinson's disease. The animals were bilaterally lesioned in the nigrostriatal pathway through a stereo...

Sleep stages classification is one of the most important methods for diagnosis in psychiatry and neurology. In this paper, a combination of three kinds of classifiers are proposed which classify the EEG signal into five sleep stages including Awake, N-REM (non-rapid eye movement) stage 1, N-REM stage 2, N-REM stage 3 and 4 (also called Slow Wave Sleep), and REM. Twenty-five all night recordings...

The pedunculopontine tegmental (PPT) GABAergic system plays a crucial role in the regulation of rapid eye movement (REM) sleep. I recently reported that the activation of PPT GABA(B) receptors suppressed REM sleep by inhibiting REM-on cells. One of the important mechanisms for GABA(B) receptor activation-mediated physiological action is the inhibition of the intracellular cAMP-dependent protein...

sleep stages classification is one of the most important methods for diagnosis in psychiatry and neurology. in this paper, a combination of three kinds of classifiers are proposed which classify the eeg signal into five sleep stages including awake, n-rem (non-rapid eye movement) stage 1, n-rem stage 2, n-rem stage 3 and 4 (also called slow wave sleep), and rem. twenty-five all night recordings...

Background & Aims: Sleep disorders are common complains in patients with cerebral stroke; studies on these issues are limited. We aimed to evaluate the sleep changes in patients with supratentorial ischemic stroke. Methods: In this cross sectional study, 38 patients (19 patients in supratentorial ischemic stroke group and 19 people in control group) were evaluated. Total sleep time, sleep effic...

Rapid eye movement sleep in males is characterized by penile erection along with EEG desynchronization, muscle atonia, ponto-geniculo-occipital waves, and rapid eye movements (REM). The central neural mechanisms regulating sleep related erections (SREs) are not known. Recently, the lateral preoptic area has been shown to contribute in sleep-related erectile mechanisms. The present study was con...