Ectopic ACTH syndrome caused by excessive production of adrenocorticotropic hormone (ACTH) a neuroendocrine tumor (NET) is an extremely rare disease, the main manifestation which pronounced hypercortisolism. In order to avoid development life-threatening complications and disability patient, timely topical diagnosis rapid decision-making on further management tactics are necessary. The problem ...

Endogenous Cushing’s syndrome (CS) is a rare endocrine disorder characterised by excess cortisol secretion due to either ACTH-dependent conditions [commonly an ACTH-producing pituitary adenoma (Cushing’s disease)] or ACTH-independent causes (with most common aetiology being benign adrenal adenoma). Overall, the annual incidence of CS ranges between 1.8 and 3.2 cases per million population. Mort...

The molecular weight of the adrenocorticotropic hormone (ACTH) activity in extracts of the separated anterior and intermediate-posterior lobes of the mouse pituitary was determined by gel filtration in guanidine-HCl. Following dilution or removal of the guanidine-HCl, ACTH activity was quantitated by both radioimmunoassay and bioassay. Extracts of the intermediate-posterior lobe contain approxi...

A double antibody immunoprecipitation technique using affinity-purified adrenocorticotropic hormone (ACTH) antiserum was employed to investigate the biosynthesis of ACTH in a mouse pituitary tumor cell line. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of cell extracts resolved four forms of ACTH with apparent molecular weights of 4,500, 13,000, 23,000, and 31,000. These four forms...

Elevated levels of corticotropin (ACTH)-reactive immunoglobulins (ACTH IgG) were found in males with conduct disorder, suggesting their involvement in the biology of antisocial behavior. We first aimed to confirm these findings in a large general population sample of adolescents. Secondly, we studied the association between ACTH IgG levels and hypothalamic-pituitary-adrenal (HPA) axis response ...

Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide hormones that get co-stored in the pituitary secretory granules. Here, we study molecular interactions between ACTH and β-endorphin and their colocalization in the form of amyloid aggregates. Although ACTH is known to be a part of A...

Both adrenocorticotropin (ACTH) and its o-nitrophenyl sulfenyl derivative (NPS-ACTH) in which the single tryptophan residue of the hormone is modified, were able to stimulate corticosterone synthesis to the same maximal rate in isolated rat adrenal cells. The concentration of NPS-ACTH required for half-maximal steroidogenesis was approximately 70 times that of ACTH. Although both ACTH and NPSAC...

the goal of this study was to evaluate the effects of quercetin and acth injection on prevention of development of morphine tolerance and dependence in mice. in this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), acth (1, 2.5, 5 iu/mice, i.p.), or combination of quercetin (5 mg/kg) and acth (1 iu/mice) once a day for four days. tolerance ...

The late-gestation plasma cortisol surge in the sheep fetus is critical for stimulating organ development and parturition. Increased adrenal responsiveness is one of the key reasons for the surge; however, the underlying mechanisms are not fully understood. Our recent studies suggest that ACTH-mediated increased expression of ACTH receptor (ACTH-R) and steroid acute regulatory protein (StAR) ma...