9-Chloro and 9-amino-2-methoxyacridines bearing different substituents in position 7, as well as their corresponding unsubstituted dimeric and tetrameric complexes, were investigated for in vitro antiproliferative properties against Leishmania infantum compared to toxicity towards human monocytes. The results clearly confirmed that several compounds of the 2-methoxyacridine series, together wit...

Sir,?I have read with great interest the article, 'A Case of Giardiasis' by H. S. Andleigh, in the June 1942 number of the Indian Medical Gazette. The author reports the striking results of treating a case of giardiasis with atebrin but does not offer any explanation for this, at first sight, surprising result. As this article may lead to further experiments with this method I may perhaps be pe...

The plant family Rutaceae is known [1, 2] to be a prolific source of furoquinoline and pyranoquinoline alkaloids. Along with them acridine alka­ loids [3, 4] have also been isolated from several members of the same plant family. Recently furanfused acridine systems such as 1 l-methylfuro(2,3-c)acridan-6(l lH)one (1) have also been reported [5-7] to occur in some rutaceous plants. Typical exampl...

Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is limited or even excluded because of side effects. Numerous synthetic methods are focused on the preparation of target acridine skeletons or modifications of naturally occurring co...

supercritical carbon dioxide has gained increasing attention in food and pharmaceutical processing owing to the fact that it is environmentally inexpensive, not flammable, essentially non-toxic, and it has a convenient critical point. also, it has been attracting much attention in many fields, such as extraction of sensitive materials and pharmaceutical processing and polymerization processes. ...

Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acr...

acridine derivatives, especially 1,8-dioxo-9-aryl-decahydroacridine represent significant scaffolds in medicinal chemistry. given the biological properties of such products which are used in drug development, they need to have appropriate carrier. proteins are generally used as helpful tools in drug delivery. consequently, molecular docking between these compounds and bovine serum albumin (bsa)...