tenecteplase is a variant of tissue plasminogen activator (t-pa) which has better pharmacokinetic properties and more selective thrombolytic activity. in the present study, we describe a rapid method to introduce three sets of mutation into defined positions in t-pa cdna by a site-directed mutagenesis based on a megaprimer pcr approach to produce tenecteplase coding sequence where amino acids a...

The size of conformational ensembles required for regular coverage of the conformational space of druglike molecules was examined. Using the conformer generation program Omega, the number of regularly distributed conformers (NRC) of flexible compounds was determined as a function of the root-mean-square deviation (RMSD) resolution of coverage. A regression equation was developed predicting the ...

A set of perception experiments, using reiterant speech, were designed to carry out a diagnostic of the segmentation / hierarchisation linguistic function of prosody. The prosodic parameters of F0, syllabic duration and intensity of the stimuli used during this experiment were extracted. Several dissimilarity measures (Correlation, root-mean-square distance and mutual information) were used to ...

Background: The presence of women in society can be considered as an important social category according to their inherent and acquired competencies and abilities. One of the necessities that has been considered in today's society is the need for women to be present in some jobs and special social responsibilities, and this necessity for attending to provide services to people in society is qui...

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This study focused on how airline managers perceive their competitive positions. Based the perceptions of managers, strengths-weaknesses-opportunities-threats (SWOT) analyses were carried out. All scheduled and unscheduled passenger carriers in Turkey used as sample for this research. The data acquired through qualitative research by semi-structured interviews with senior executives airlines. d...

Introduction Echo-planar imaging (EPI) suffers from ghosting artifacts if the sample positions in k-space are not accurately known. Many effects lead to a distortion of the ideal gradient waveforms and cause differences in the sample positions for echoes acquired with positive and negative readout gradient polarity. Various methods have been developed to compensate for them, which rely on eithe...

This paper presents results of an experiment integrating information from valency dictionary of Polish into a mention detection system. Two types of information is acquired: positions of syntactic schemata for nominal and verbal constructs and secondary prepositions present in schemata. The syntactic schemata are used to prevent (for verbal realizations) or encourage (for nominal groups) constr...

Background Cardiac magnetic resonance (CMR) can be used to quantify cardiac mechanics from images that are generally acquired during an end-expiratory breath-hold. Unfortunately, it is difficult for subjects to hold their breath at the exact same position when undergoing a series of breath-holds during a typical CMR study. The effect of patient-specific variability in breath-hold positions on m...

purpose this study was performed to introduce and evaluate the potential of kinematic magnetic resonance imaging (kmri) using a high-field open-magnet magnetic resonance (mr) system. methods we attempted to perform kmri of healthy volunteers’ lumbar spine and knee in the lateral position and ankle in the supine position utilizing the superconducting, horizontally opened, 1.2 t mr system (oasis,...