Abstract: Sulforaphane (SPN) is reported to activate the Nrf2/Keap1 complex responsible for protein and gene expression promotion of various antioxidant enzymes. The present study examined role Nrf2 in modulating other signaling pathways involved SPN’s attenuation acrolein (ACL)-induced cardiomyopathy rats. Forty-two rat was categorized into seven 4-week treatment groups: control, SPN, losartan...

Background: Many factors affect the outcomes of anterior cruciate ligament (ACL) reconstruction surgery. However, few studies have examined effects local bone conditions on ACL. This study investigated changes in mineral density (BMD) knee after rupture ACL with view using this information to guide treatment options.

A major hurdle in investigating important clinical questions in knee ligament treatment is a lack of valid translational animal models. This study characterizes the effects of partial transection versus synovial debridement of the anterior (cranial) cruciate ligament (ACL) in dogs. A total of 27 adult purpose-bred research hounds underwent surgery and were assessed over the following 8 weeks. D...

 Background: A rare and devastating complication following anterior cruciate ligament (ACL) revision reconstruction is femoral fracture.    Case presentation: A 35-year old male soccer player with a history of ACL tear from the previous year ago, who underwent arthroscopic ACL reconstruction and functioned well until another similar injury caused ACL re-rupture. Revision of ACL reconstruction w...

BACKGROUND The purpose of this study was to measure the tibiofemoral kinematics of anterior cruciate ligament (ACL) deficiency in a Chinese population and compare the kinematics with published data about a Caucasian population. METHODS Unilateral knees of 18 Chinese ACL-deficient (ACL-D) subjects were studied while subjects ascended stairs. Kinematic alteration was compared between ACL-D knee...

objective: the clinical value of igg anticardiolipin antibody in patients with behçet's disease with or without vascular thrombosis was evaluated.   methods: igg isotype of anticardiolipin (acl) antibody was assessed in 40 behçet's disease (bd) patients with venous or arterial thrombosis, 40 bd patients without venous or arterial thrombosis and 80 healthy subjects as controls. the lev...

The number of primary anterior cruciate ligament (ACL) tears is rapidly increasing. In patients who wish to return to their preoperative level of function, specifically as it pertains to participation in sports, the gold standard of treatment following an ACL tear remains an anterior cruciate ligament (ACL) reconstruction. Despite a majority of good/excellent results following primary ACL recon...

Accurate knowledge of in vivo anterior cruciate ligament (ACL) forces is instrumental for understanding normal ACL function and improving surgical ACL reconstruction techniques. The objective of this study was to estimate the change in ACL forces under in vivo loading conditions using a noninvasive technique. A combination of magnetic resonance and dual fluoroscopic imaging system was used to d...