Epithelial inclusions were detected in myocardium of a 2-month-old male Holstein calf. Microscopically,nonpurulent myocarditis along with focal tubular and acinar structures covered with cuboidal epithelial cellswas seen in the myocardium. Most tubular and acinar structures stained with Masson’s trichrome were foundto be surrounded with a dense collagen. Tubular and acinar structures had PAS po...

Physiological calcium (Ca(2+)) signals within the pancreatic acinar cell regulate enzyme secretion, whereas aberrant Ca(2+) signals are associated with acinar cell injury. We have previously identified the ryanodine receptor (RyR), a Ca(2+) release channel on the endoplasmic reticulum, as a modulator of these pathological signals. In the present study, we establish that the RyR is expressed in ...

Several important characteristics of exocrine pancreatic tumor pathogenesis remain incompletely defined, including identification of the cell of origin. Most human pancreatic neoplasms are ductal adenocarcinomas. However, acinar cells have been proposed as the source of some ductal neoplasms through a process of acinar-to-ductal metaplasia. The oncogenic transcription factor c-myc is associated...

Previous studies show that culturing an immortalized human submandibular gland cell line (HSG) on Matrigel, a basement membrane extract, induces cytodifferentiation. We have further defined this model system and identified factors involved in HSG cell acinar development and cyto-differentiation. Acinar development is marked by cell migration into multi-cellular spherical structures, cell prolif...

A 70-year-old man was admitted to the Emergency Department (ED) for marked asthenia and severe anemia. In addition, a high level of lipase found. During hospitalization, locally advanced gastric cancer diagnosed, with endoscopic evidence large polyploid formation originating under cardias that occupied most lumen. total body CT scan performed before surgery; tumor affected posterior wall, tenac...

Ultrastructural studies have shown that many exocrine glands receive their autonomic innervation through close (180-250 A) apposition of the nerve and acinar cell membranes (1, 5, 14, 16, 17, 20, 23-25). The nerve terminations or varicosities often lie in a groove on the surface of the acinar cell, or are closely apposed to two or more acinar cells by lying in the intercellular space between th...

A promising approach to new diabetes therapies is to generate β cells from other differentiated pancreatic cells in vivo. Because the acinar cells represent the most abundant cell type in the pancreas, an attractive possibility is to reprogram acinar cells into β cells. The transcription factor Pdx1 (Pancreas/duodenum homeobox protein 1) is essential for pancreatic development and cell lineage ...

The secretory acinar cells of the salivary gland are essential for saliva secretion, but are also the cell type preferentially lost following radiation treatment for head and neck cancer. The source of replacement acinar cells is currently a matter of debate. There is evidence for the presence of adult stem cells located within specific ductal regions of the salivary glands, but our laboratory ...

Gabapentin induces pancreatic acinar cell tumors in rats through unknown, yet apparently nongenotoxic mechanisms. The primary objective of this study was to determine whether gabapentin acts as a tumor promoter by stimulating acinar cell proliferation in rat pancreas. To this end, indices of pancreatic growth, including increased pancreatic weight, stimulation of acinar cell proliferation, and/...

Context Acinar cell cystadenoma of pancreas is a very rare pancreatic cystic lesion. It is also a benign lesion without malignant potential. Because it is normal tissue with abnormal figuration, acinar cell transformation is also named. Case report We reported a thirty-sevenyear-old female noticed to have a cystic lesion closely in contact with the pancreatic tail by abdominal CT scan. After op...