Treatment of O-acyl lipids with hydrazine degrades them to hydrazides of the constituent fatty acids. These hydrazides react with acetone to yield less polar and more volatile N'-isopropylidenealkanohydrazides, R-CO-NH-N = C(CH3)2, which strongly absorb ultraviolet light and are amenable to thin-layer and gas-liquid chromatographic analyses. In presence of cyclopentene, reduction of double bond...

Schiff bases of fatty acid hydrazides made from Oil recovered from spent bleaching earth (ORSBE) and Acid oil (AO)were prepared. These newly synthesized Schiff bases were characterized on the basis of FT-IR, elemental analysis and evaluated for biological performance. Schiff bases exhibited mild antibacterial activities against certain micro-organisms if compared with streptomycin used as stand...

In peptide synthesis, hydrazides are important intermediates for the azide coupling method. A hydrazide is converted to the corresponding azide in the presence of an acid and a nitrite. When acetic acid (or formic acid) is used as the acid, partial acetylation (or formylation) of the hydrazide occurs as a side reaction. Formylation of the hydrazide is much faster than acetylation. Removal of th...

Phenylhydrazines 1 substituted with two or three long-chain alkyl, alkoxy or alkylsulfanyl groups were successfully prepared by acid-induced removal of the Boc group in hydrazides 2. The reaction is carried out with 5 equivalents of TfOH in CF(3)CH(2)OH/CH(2)Cl(2) at -40 °C for 1.5 min. Under these conditions, the deprotected hydrazine 1 is fully protonated, which increases its stability in the...

Despite their high efficacy NSAIDs have significant side effects due to non-selective inhibition of COX-1 and COX-2. Due this, medical chemists still pay considerable attention design synthesis, in particular the creation hybrid molecules that combine structure a fragment with anti-inflammatory activity quinazoline heterocycle.
 The aim present study is develop methods for synthesis [1,2,4...

Abstract Novel hydrazone and 1,2,4-triazole-3-thione derivatives were obtained via the reaction of N 1 , 3 ,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with acid hydrazides thiosemicarbazide, respectively. Structure products was proved using IR H NMR spectroscopy methods. Some synthesized compounds tested for antimicrobial activity